ArticleMolecular medicine (Cambridge, Mass.)
Neoplastic transformation of human small airway epithelial cells induced by arsenic.
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- Matrine Suppresses Arsenic-Induced Malignant Transformation of SV-HUC-1 Cells via NOX2.International journal of molecular sciences · 2024Article
- Chronic arsenic increases cell migration in BEAS-2B cells by increasing cell speed, cell persistence, and cell protrusion length.Experimental cell research · 2021Article
- p38α MAPK is required for arsenic-induced cell transformation.Molecular carcinogenesis · 2016Article
- Arsenite Regulates Prolongation of Glycan Residues of Membrane Glycoprotein: A Pivotal Study via Wax Physisorption Kinetics and FTIR Imaging.International journal of molecular sciences · 2016Article
- Article
- Arsenic is cytotoxic and genotoxic to primary human lung cells.Mutation research. Genetic toxicology and environmental mutagenesis · 2014Article
- Molecular features in arsenic-induced lung tumors.Molecular cancer · 2013Review
- CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure.European journal of histochemistry : EJH · 2013Article
- Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by α-particles.International journal of cancer · 2013Article
- Arsenic, asbestos and radon: emerging players in lung tumorigenesis.Environmental health : a global access science source · 2012Review
- Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation.The Journal of biological chemistry · 2012Article
- Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells.Toxicology and applied pharmacology · 2012Article
- Article
- Transforming growth factor-β-induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway.International journal of oncology · 2011Article
- Arsenic exposure and the induction of human cancers.Journal of toxicology · 2011Article
- Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells.Environmental health perspectives · 2010Article
- Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2.Free radical biology & medicine · 2008Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human small airway epithelial cells (SAECs) previously immortalized with human telomerase reverse transcriptase (h-TERT) were continuously treated with sodium arsenite at a dose of 0.5 microg/mL in culture for up to 6 months. Arsenic-treated cells progressively displayed an increase in transformed phenotype including enhanced growth saturation density, plating efficiency, and anchorage-independent growth and invasion capability compared with their nontreated control cells. To determine whether arsenic-induced cell transformation was associated with genomic instability, treated and control cells were also analyzed for micronuclei formation. A 4.8-fold increase in micronuclei incidence in arsenic-treated cells was detected in conjunction with increased N-phosphonacetyl-l-aspartate (PALA)-resistant characteristics. In addition, arsenic-treated cells showed an increase in c-H-ras, c-myc, and c-fos protein expression relative to controls. The change in oncoprotein expression correlated with a decrease in wild-type p53 expression and hyperphosphorylated retinoblastoma. Taken together, these results strongly suggest that h-TERT immortalized human small airway epithelial cells underwent step-wise transformation after inorganic arsenic treatment.
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