ReviewBritish journal of pharmacology2008
Ligand discovery and virtual screening using the program LIDAEUS.
Review in British journal of pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- A Review on Parallel Virtual Screening Softwares for High-Performance Computers.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Design of drug-like hepsin inhibitors against prostate cancer and kidney stones.Acta pharmaceutica Sinica. B · 2020Article
- Mimicking Strategy for Protein-Protein Interaction Inhibitor Discovery by Virtual Screening.Molecules (Basel, Switzerland) · 2019Review
- Inhibition of Oncogenic Kinases: An In Vitro Validated Computational Approach Identified Potential Multi-Target Anticancer Compounds.Biomolecules · 2019Article
- PLK1, A Potential Target for Cancer Therapy.Translational oncology · 2017Review
- Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin.Chemical science · 2015Article
- Article
- Structure- and ligand-based virtual screening identifies new scaffolds for inhibitors of the oncoprotein MDM2.PloS one · 2015Article
- Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening.BMC bioinformatics · 2012Article
- Large-scale integrated super-computing platform for next generation virtual drug discovery.Current opinion in chemical biology · 2011Review
- Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus.BMC bioinformatics · 2011Article
- Chemical biologists gather in Heidelberg.Nature chemical biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
This paper discusses advances in docking and scoring approaches with examples from the high-throughput virtual screening program LIDAEUS. We describe the discovery of small molecule inhibitors for the immunophilin CypA, the cyclin-dependent kinase CDK2 and the cyclapolin series of potent Polo-like kinase inhibitors. These results are discussed in the context of advances in massively parallel computing and in the development of annotated databases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.