ArticleDNA repair2008
Brca1 in immunoglobulin gene conversion and somatic hypermutation.
Article in DNA repair, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications.Frontiers in immunology · 2024Review
- BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1.Nature communications · 2022Article
- SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Review
- Genome complexity in the coelacanth is reflected in its adaptive immune system.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2014Article
- MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils.Nucleic acids research · 2013Article
- The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy.Cell & bioscience · 2013Article
- A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network.Nucleic acids research · 2012Article
- RAD51 paralogs promote homology-directed repair at diversifying immunoglobulin V regions.BMC molecular biology · 2009Article
- Temporal regulation of Ig gene diversification revealed by single-cell imaging.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- The current structural and functional understanding of APOBEC deaminases.Cellular and molecular life sciences : CMLS · 2009Review
- The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.Cancer cell · 2009Article
- Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.PLoS genetics · 2009Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Defects in Brca1 confer susceptibility to breast cancer and genomic instability indicative of aberrant repair of DNA breaks. Brca1 was previously implicated in the homologous recombination pathway via effects on the assembly of recombinase Rad51. Activation-induced cytidine deaminase (AID) deaminates C to U in B lymphocyte immunoglobulin (Ig) DNA to initiate programmed DNA breaks. Subsequent uracil-glycosylase mediated U removal, and perhaps further processing, leads to four known classes of mutation: Ig class switch recombination that results in a region-specific genomic deletion, Ig somatic hypermutation that introduces point mutations in Ig V-regions, Ig gene conversion in vertebrates that possess Ig pseudo-V genes, and translocations common to B cell lymphomas. We tested the involvement of Brca1 in AID-dependent Ig diversification in chicken DT40 cells. The DT40 cell line diversifies IgVlambda mainly by gene conversion, and less so by point mutation. Brca1-deficiency caused a shift in Vlambda diversification, significantly reducing the proportion of gene conversions relative to point mutations. Thus, Brca1 regulates AID-dependent DNA lesion repair. Interestingly, while Brca1 is required to recruit ubiquitinated FancD2 to DNA damage, the phenotype of Brca1-deficient DT40 differs from the one of FancD2-deficient DT40, in which both gene conversion and non-templated mutations are impaired.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.