Trial reportProstaglandins, leukotrienes, and essential fatty acids
Heparin, lipoproteins, and oxygenated fatty acids in blood: a cautionary note.
Trial report in Prostaglandins, leukotrienes, and essential fatty acids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Gonadotropin response to insulin and lipid infusion reproduces the reprometabolic syndrome of obesity in eumenorrheic lean women: a randomized crossover trial.Fertility and sterility · 2021Trial
- Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids.Molecular nutrition & food research · 2013Trial
- Unfractionated heparin reverses aspirin inhibition of platelets during coronary artery bypass graft surgery.Scientific reports · 2024Article
- Myocardial glucose suppression may interfere with the detection of inflammatory cells with FDG-PET as suggested in a canine model of myocardial infarction.EJNMMI research · 2023Article
- Effect of cardiopulmonary bypass on plasma and erythrocytes oxylipins.Lipids in health and disease · 2023Observational
- Heparin Effects on Serum Gonadotropins.Journal of the Endocrine Society · 2022Article
- Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis.Antioxidants (Basel, Switzerland) · 2021Article
- Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma.Prostaglandins, leukotrienes, and essential fatty acids · 2019Article
- Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins.Cell chemical biology · 2019Article
- Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery.Journal of translational medicine · 2017Observational
- Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men.Prostaglandins, leukotrienes, and essential fatty acids · 2013Article
- Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery.Analytical and bioanalytical chemistry · 2012Article
- Anticoagulants influence the in vitro activity and composition of shock lymph but not its in vivo activity.Shock (Augusta, Ga.) · 2011Article
- Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation.Journal of lipid research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We measured 16 nonesterified oxygenated fatty acid derivatives (oxylipids) in plasmas from seven human subjects. Two arterial samples from each subject were analyzed, drawn approximately 2h apart. We observed a marked increase in levels of most oxylipids in the second sample, as high as 470-fold. Between the first and second samples, subjects received approximately 800-1000 IU of heparin to prevent clotting in intravascular catheters. We postulate that heparin activated lipoprotein lipases, which, in turn, released oxylipids from triglycerides and phospholipids in plasma lipoproteins. Some of that lipolysis may have occurred during sample storage. Measurements of nonesterified lipids in human plasma may be distorted if heparin is administered to subjects before blood is drawn and if lipase inhibitors are omitted from stored samples.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.