ArticleArthritis research & therapy2007
Gait analysis in a murine model of collagen-induced arthritis.
Article in Arthritis research & therapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Vestibular nucleus stimulation for ameliorating locomotor dynamics in a Parkinsonian mouse model.Nature communications · 2026Article
- The common and specific osteoarthritis gait characteristics: A quantitative grading system for OA associated gait changes in mice.Osteoarthritis and cartilage open · 2026Article
- COMPREHENSIVE ANALYSIS OF MURINE GAIT DURING SKELETAL MATURATION.bioRxiv : the preprint server for biology · 2026Article
- Narirutin mitigates inflammatory arthritis and osteoporosis through modulating macrophage phenotype and osteoclastogenesis.Journal of orthopaedic translation · 2025Article
- Inner and outer penetrating spinal cord injuries lead to distinct overground walking in mice.IBRO neuroscience reports · 2024Article
- Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke.Brain, behavior, and immunity · 2024Article
- Inhibitory effects of Acanthopanax sessiliflorus Harms extract on the etiology of rheumatoid arthritis in a collagen-induced arthritis mouse model.Arthritis research & therapy · 2024Article
- Betulin Accelerated the Functional Recovery of Injured Muscle in a Mouse Model of Muscle Contusion.International journal of medical sciences · 2024Article
- Repeated epidural delivery of Shinbaro2: effects on neural recovery, inflammation, and pain modulation in a rat model of lumbar spinal stenosis.Frontiers in pharmacology · 2024Article
- Chemically modified small interfering RNA targeting Hedgehog signaling pathway for rheumatoid arthritis therapy.Molecular therapy. Nucleic acids · 2023Article
- Bench to Bedside: Modelling Inflammatory Arthritis.Discovery immunology · 2023Review
- Quadruped Gait and Regulation of Apoptotic Factors in Tibiofemoral Joints following Intra-Articular rhPRG4 Injection inInternational journal of molecular sciences · 2022Article
- Ligamentous injury-induced ankle instability causing posttraumatic osteoarthritis in a mouse model.BMC musculoskeletal disorders · 2022Article
- Primary Osteoarthritis Early Joint Degeneration Induced by Endoplasmic Reticulum Stress Is Mitigated by Resveratrol.The American journal of pathology · 2021Article
- Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage.Aging and disease · 2021Article
- Refinement and validation of infrared thermal imaging (IRT): a non-invasive technique to measure disease activity in a mouse model of rheumatoid arthritis.Arthritis research & therapy · 2020Article
- That's a Wrap! Molecular Drivers Governing Neuronal Nogo Receptor-Dependent Myelin Plasticity and Integrity.Frontiers in cellular neuroscience · 2020Review
- Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis.Arthritis research & therapy · 2019Article
- Article
- Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice.Osteoarthritis and cartilage · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Murine collagen-induced arthritis (CIA) has become a valuable animal model for elucidating pathogenic mechanisms and evaluating therapeutic effects for rheumatoid arthritis. Recent advances in digital imaging and computer technology have enabled gait analysis to develop into a powerful tool for objectively detecting functional deficits in human and animal models. The present study explored the use of non-invasive video-capture gait analysis in the evaluation of a murine CIA model. CIA was induced in 45 female DBA/1LacJ mice (8 to 10 weeks old) by immunization with lyophilized bovine articular type II collagen. Gait parameters were determined by ventral plane videography and were correlated to traditional arthritis clinical scores. Our results showed that increases in clinical scores that measure the severity of CIA corresponded to changes in multiple gait parameters that reflect both morphologic (increases in paw area) and functional (increase in stride frequency, decrease in stride length, hind-limb paw placement angle, as well as stride, stance, and braking times) deficits. Our work indicated that the non-invasive video-capture device may be used as a simple and objective data acquisition system for quantifying gait disturbances in CIA mice for the investigation of mechanisms and the evaluation of therapeutic agents.
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