ArticleBMC developmental biology2007
Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells.
Article in BMC developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent CaCell calcium · 2024Article
- Unraveling the interplay: exploring signaling pathways in pancreatic cancer in the context of pancreatic embryogenesis.Frontiers in cell and developmental biology · 2024Review
- Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals.Nature communications · 2021Article
- Pancreatic islet regeneration through PDX-1/Notch-1/Ngn3 signaling after gastric bypass surgery in db/db mice.Experimental and therapeutic medicine · 2017Article
- Single cell transcriptomic profiling of mouse pancreatic progenitors.Physiological genomics · 2017Article
- PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells.Stem cell reports · 2015Article
- Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival.Developmental biology · 2014Article
- Transcriptional control of mammalian pancreas organogenesis.Cellular and molecular life sciences : CMLS · 2014Review
- Sox9: a master regulator of the pancreatic program.The review of diabetic studies : RDS · 2014Review
- Profiling of embryonic stem cell differentiation.The review of diabetic studies : RDS · 2014Review
- A Sox9/Fgf feed-forward loop maintains pancreatic organ identity.Development (Cambridge, England) · 2012Article
- Organogenesis and functional genomics of the endocrine pancreas.Cellular and molecular life sciences : CMLS · 2012Review
- Research resource: the pdx1 cistrome of pancreatic islets.Molecular endocrinology (Baltimore, Md.) · 2012Article
- RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors.Molecular and cellular biology · 2012Article
- Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis.Developmental biology · 2011Article
- A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system.PLoS genetics · 2011Article
- An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.BMC developmental biology · 2011Article
- Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.Genome research · 2010Article
- Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development.BMC developmental biology · 2009Article
- On the origin of the beta cell.Genes & development · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe homeodomain transcription factor IPF1/PDX1 exerts a dual role in the pancreas; Ipf1/Pdx1 global null mutants fail to develop a pancreas whereas conditional inactivation of Ipf1/Pdx1 in beta-cells leads to impaired beta-cell function and diabetes. Although several putative target genes have been linked to the beta-cell function of Ipf1/Pdx1, relatively little is known with respect to genes regulated by IPF1/PDX1 in early pancreatic progenitor cells.
resultsMicroarray analyses identified a total of 111 genes that were differentially expressed in e10.5 pancreatic buds of Ipf1/Pdx1-/- embryos. The expression of one of these, Spondin 1, which encodes an extracellular matrix protein, has not previously been described in the pancreas. Quantitative real-time RT-PCR analyses and immunohistochemical analyses also revealed that the expression of FgfR2IIIb, that encodes the receptor for FGF10, was down-regulated in Ipf1/Pdx1-/- pancreatic progenitor cells.
conclusionThis microarray analysis has identified a number of candidate genes that are differentially expressed in Ipf1/Pdx1-/- pancreatic buds. Several of the differentially expressed genes were known to be important for pancreatic progenitor cell proliferation and differentiation whereas others have not previously been associated with pancreatic development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.