ArticleMolecular microbiology2008
LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Type 1 fimbria and P pili: regulatory mechanisms of the prototypical members of the chaperone-usher fimbrial family.Archives of microbiology · 2024Review
- Newly identified pathogens in periodontitis: evidence from an association and an elimination study.Journal of oral microbiology · 2023Article
- Gut-bladder axis enters the stage: Implication for recurrent urinary tract infections.Cell host & microbe · 2022Article
- Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- What Flips the Switch? Signals and Stress Regulating Extraintestinal PathogenicMicroorganisms · 2021Review
- Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies.Nature reviews. Microbiology · 2020Review
- Pathogenicity Factors of Genomic Islands in Intestinal and ExtraintestinalFrontiers in microbiology · 2020Review
- The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone.Scientific reports · 2019Article
- Article
- Involvement of NLRP3 and NLRC4 Inflammasome in UropathogenicFrontiers in microbiology · 2019Article
- Comparative Genome Analysis of UropathogenicFrontiers in cellular and infection microbiology · 2019Article
- Regulation of hemolysin in uropathogenic Escherichia coli fine-tunes killing of human macrophages.Virulence · 2018Article
- Hemolytic Escherichia coli Inhibits Swarming and Differentiation of Proteus mirabilis.Current microbiology · 2018Article
- Altered Regulation of the Diguanylate Cyclase YaiC Reduces Production of Type 1 Fimbriae in a Pst Mutant of Uropathogenic Escherichia coli CFT073.Journal of bacteriology · 2017Article
- Bacterial virulence phenotypes ofScience translational medicine · 2017Article
- Temporal Regulation ofJournal of pathogens · 2017Article
- The UbiI (VisC) Aerobic Ubiquinone Synthase Is Required for Expression of Type 1 Pili, Biofilm Formation, and Pathogenesis in Uropathogenic Escherichia coli.Journal of bacteriology · 2016Article
- Comprehensive mutagenesis of the fimS promoter regulatory switch reveals novel regulation of type 1 pili in uropathogenic Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections.Microbiology spectrum · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Uropathogenic Escherichia coli (UPEC) contain multiple horizontally acquired pathogenicity-associated islands (PAI) implicated in the pathogenesis of urinary tract infection. In a murine model of cystitis, type 1 pili-mediated bladder epithelial invasion and intracellular proliferation are key events associated with UPEC virulence. In this study, we examined the mechanisms by which a conserved PAI contributes to UPEC pathogenesis in acute cystitis. In the human UPEC strain UTI89, spontaneous excision of PAI II(UTI89) disrupts the adjacent leuX tRNA locus. Loss of wild-type leuX-encoded tRNA(5)(Leu) significantly delayed, but did not eliminate, FimB recombinase-mediated phase variation of type 1 pili. FimX, an additional FimB-like, leuX-independent recombinase, was also found to mediate type 1 pili phase variation. However, whereas FimX activity is relatively slow in vitro, it is rapid in vivo as a non-piliated strain lacking the other fim recombinases rapidly expressed type 1 pili upon experimental infection. Finally, we found that disruption of leuX, but not loss of PAI II(UTI89) genes, reduced bladder epithelial invasion and intracellular proliferation, independent of type 1 piliation. These findings indicate that the predominant mechanism for preservation of PAI II(UTI89) during the establishment of acute cystitis is maintenance of wild-type leuX, and not PAI II(UTI89) gene content.
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