ArticleJournal of molecular histology2008
Tissue distribution of quiescin Q6/sulfhydryl oxidase (QSOX) in developing mouse.
Article in Journal of molecular histology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases.The EMBO journal · 2023Article
- Secretory mouse quiescin sulfhydryl oxidase 1 aggregates defected human and mouse spermatozoa in vitro and in vivo.iScience · 2021Article
- Quiescin/sulfhydryl oxidase 1b (QSOX1b) induces migration and proliferation of vascular smooth muscle cells by distinct redox pathways.Archives of biochemistry and biophysics · 2020Article
- Identification, characterization and purification of porcine Quiescin Q6-Sulfydryl Oxidase 2 protein.BMC veterinary research · 2017Article
- Immunohistochemical expression of sulfhydryl oxidase (QSOX1) in pediatric medulloblastomas.Diagnostic pathology · 2015Article
- The emerging role of QSOX1 in cancer.Antioxidants & redox signaling · 2014Review
- Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes.Journal of cellular and molecular medicine · 2014Article
- Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas.European journal of histochemistry : EJH · 2014Article
- Proteolytic processing of QSOX1A ensures efficient secretion of a potent disulfide catalyst.The Biochemical journal · 2013Article
- Expression of quiescin sulfhydryl oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in Luminal B breast cancer.Breast cancer research : BCR · 2013Article
- Protein substrate discrimination in the quiescin sulfhydryl oxidase (QSOX) family.Biochemistry · 2012Article
- Quiescin sulfhydryl oxidase (QSOX) is expressed in the human atheroma core: possible role in apoptosis.In vitro cellular & developmental biology. Animal · 2011Article
- Oxidative protein folding and the Quiescin-sulfhydryl oxidase family of flavoproteins.Antioxidants & redox signaling · 2010Review
- Effect of TNF-alpha on human ARPE-19-secreted proteins.Molecular vision · 2008Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quiescin Q6/sulfhydryl oxidases (QSOX) are revisited thiol oxidases considered to be involved in the oxidative protein folding, cell cycle control and extracellular matrix remodeling. They contain thioredoxin domains and introduce disulfide bonds into proteins and peptides, with the concomitant hydrogen peroxide formation, likely altering the redox environment. Since it is known that several developmental processes are regulated by the redox state, here we assessed if QSOX could have a role during mouse fetal development. For this purpose, an anti-recombinant mouse QSOX antibody was produced and characterized. In E(13.5), E(16.5) fetal tissues, QSOX immunostaining was confined to mesoderm- and ectoderm-derived tissues, while in P1 neonatal tissues it was slightly extended to some endoderm-derived tissues. QSOX expression, particularly by epithelial tissues, seemed to be developmentally-regulated, increasing with tissue maturation. QSOX was observed in loose connective tissues in all stages analyzed, intra and possibly extracellularly, in agreement with its putative role in oxidative folding and extracellular matrix remodeling. In conclusion, QSOX is expressed in several tissues during mouse development, but preferentially in those derived from mesoderm and ectoderm, suggesting it could be of relevance during developmental processes.
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