ArticleEMBO reports2008
Differential in vivo requirements for oligomerization during Groucho-mediated repression.
Article in EMBO reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 29 citations in OpenAlex.
- Normal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase.Development (Cambridge, England) · 2023Article
- Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness inDevelopment (Cambridge, England) · 2018Article
- Article
- Mechanisms of Groucho-mediated repression revealed by genome-wide analysis of Groucho binding and activity.BMC genomics · 2017Article
- Groucho restricts rhomboid expression and couples EGFR activation with R8 selection during Drosophila photoreceptor differentiation.Developmental biology · 2015Article
- The Groucho co-repressor is primarily recruited to local target sites in active chromatin to attenuate transcription.PLoS genetics · 2014Article
- O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonical Wnt signaling.The Journal of biological chemistry · 2014Article
- Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila.PLoS genetics · 2013Article
- Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types.Development (Cambridge, England) · 2013Article
- GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos.PloS one · 2013Article
- Pleiohomeotic interacts with the core transcription elongation factor Spt5 to regulate gene expression in Drosophila.PloS one · 2013Article
- The unconserved groucho central region is essential for viability and modulates target gene specificity.PloS one · 2012Article
- New insights into the Orange domain of E(spl)-M8, and the roles of the C-terminal domain in autoinhibition and Groucho recruitment.Molecular and cellular biochemistry · 2011Article
- Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression.The EMBO journal · 2011Article
- Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila.Development (Cambridge, England) · 2011Article
- AES/GRG5: more than just a dominant-negative TLE/GRG family member.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
- DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers.Nucleic acids research · 2010Article
- Cofactor-activated phosphorylation is required for inhibition of cortical neuron differentiation by Groucho/TLE1.PloS one · 2009Article
- Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- On the mechanism underlying the divergent retinal and bristle defects of M8* (E(spl)D) in Drosophila.Genesis (New York, N.Y. : 2000) · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Groucho (Gro)/transducin-like enhancer of split family of transcriptional corepressors are implicated in many signalling pathways that are important in development and disease, including those mediated by Notch, Wnt and Hedgehog. Here, we describe a genetic screen in Drosophila that yielded 50 new gro alleles, including the first protein-null allele, and has two mutations in the conserved Q oligomerization domain that have been proposed to have an essential role in corepressor activity. One of these latter mutations, encoding an amino-terminal protein truncation that lacks part of the Q domain, abolishes oligomerization in vitro and renders the protein unstable in vivo. Nevertheless, the mutation is not a null: maternal mutant embryos have intermediate segmentation phenotypes and relatively normal terminal patterning suggesting that the mutant protein retains partial corepressor activity. Our results show that homo-oligomerization of Gro is not obligatory for its action in vivo, and that Gro represses transcription through more than one molecular mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.