ArticleNucleic acids research2008
CpG methylation plays a vital role in determining tissue- and cell-specific expression of the human cell-death-inducing DFF45-like effector A gene through the regulation of Sp1/Sp3 binding.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Prognostic value of SPARC in hepatocellular carcinoma: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Epigenetic silencing ofOncology reports · 2025Article
- Article
- Hypermethylation-Mediated Silencing ofInternational journal of molecular sciences · 2022Article
- Blood-Based Epigenetic Markers ofJournal of the American Heart Association · 2021Article
- LncSEA: a platform for long non-coding RNA related sets and enrichment analysis.Nucleic acids research · 2021Article
- Article
- Distribution Patterns of DNA N6-Methyladenosine Modification in Non-coding RNA Genes.Frontiers in genetics · 2020Article
- Down-Regulation of CIDEA Promoted Tumor Growth and Contributed to Cisplatin Resistance by Regulating the JNK-p21/Bad Signaling Pathways in Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2020Article
- Lnc2Meth: a manually curated database of regulatory relationships between long non-coding RNAs and DNA methylation associated with human disease.Nucleic acids research · 2018Article
- Chronic hypoxia upregulates DNA methyltransferase and represses large conductance Ca2+-activated K+ channel function in ovine uterine arteries.Biology of reproduction · 2017Article
- CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells.BMC ophthalmology · 2016Article
- PPARγ regulated CIDEA affects pro-apoptotic responses in glioblastoma.Cell death discovery · 2015Article
- A global profile of gene promoter methylation in treatment-naïve urothelial cancer.Epigenetics · 2014Article
- Gene expression and nucleotide composition are associated with genic methylation level in Oryza sativa.BMC bioinformatics · 2014Article
- Rosa26 locus supports tissue-specific promoter driving transgene expression specifically in pig.PloS one · 2014Article
- Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4).Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Aberrant methylation of SPARC in human hepatocellular carcinoma and its clinical implication.World journal of gastroenterology · 2012Article
- CIDE-3 interacts with lipopolysaccharide-induced tumor necrosis factor, and overexpression increases apoptosis in hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2011Article
- Promoter analysis of mouse Scn3a gene and regulation of the promoter activity by GC box and CpG methylation.Journal of molecular neuroscience : MN · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-death-inducing DFF45-like effector A (CIDE-A) belongs to a family of proapoptotic proteins, the expression of which is highly restricted in human tissues and cells. Here, the core region of the human CIDE-A promoter was characterized. Surprisingly, two Sp1/Sp3-binding sites, rather than tissue-specific transcription factors, were found to be required for the promoter activity. Although the ubiquitously expressed Sp1 and Sp3 were crucial, they alone could not adequately regulate the specific expression of CIDE-A. We found that the expression of CIDE-A was further regulated by CpG methylation of the promoter region. By performing bisulfite sequencing, we observed dense CpG methylation of the promoter region in tissues and cells with low or no expression of CIDE-A but not in tissues with high level of CIDE-A expression. In vitro methylation of this region showed significantly reduced transcriptional activity. Treatment of CIDE-A-negative cells with 5-aza-2'-deoxycytidine demethylated the CpG sites; this opened the closed chromatin conformation and markedly enhanced the binding affinity of Sp1/Sp3 to the promoter in vivo, thereby restoring CIDE-A expression. These data indicated that CpG methylation plays a crucial role in establishing and maintaining tissue- and cell-specific transcription of the CIDE-A gene through the regulation of Sp1/Sp3 binding.
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