ReviewSchizophrenia bulletin2008
Schizophrenia, psychiatric genetics, and Darwinian psychiatry: an evolutionary framework.
Review in Schizophrenia bulletin, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methylenetetrahydrofolate reductase A1298C genetic variant& risk of schizophrenia: A meta-analysis.The Indian journal of medical research · 2017Pooled it
- Understanding the Emergence of Schizophrenia in the Light of Human Evolution: New Perspectives in Genetics.Genes, brain, and behavior · 2025Review
- Asian-European differentiation of schizophrenia-associated genes driven by admixture and natural selection.iScience · 2024Article
- The burden of schizophrenia in the Middle East and North Africa region, 1990-2019.Scientific reports · 2024Article
- Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants.European archives of psychiatry and clinical neuroscience · 2022Article
- No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia.Schizophrenia bulletin · 2020Article
- Social Cognition Analyzer Application-A New Method for the Analysis of Social Cognition in Patients Diagnosed With Schizophrenia.Frontiers in psychiatry · 2019Article
- Altered frontal white matter asymmetry and its implications for cognition in schizophrenia: A tractography study.NeuroImage. Clinical · 2019Article
- Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression.American journal of human genetics · 2017Article
- Genetic Markers of Human Evolution Are Enriched in Schizophrenia.Biological psychiatry · 2016Article
- Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function.Schizophrenia bulletin · 2015Article
- Exceptional visuospatial imagery in schizophrenia; implications for madness and creativity.Frontiers in human neuroscience · 2013Article
- Social motor coordination in unaffected relatives of schizophrenia patients: a potential intermediate phenotype.Frontiers in behavioral neuroscience · 2013Article
- Mass spectrometric analysis of prefrontal cortex proteins in schizophrenia and bipolar disorder.SpringerPlus · 2012Article
- A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia.NeuroImage · 2010Article
- Genetic associations of brain structural networks in schizophrenia: a preliminary study.Biological psychiatry · 2010Article
- Autonomic dysfunction in unaffected first-degree relatives of patients suffering from schizophrenia.Schizophrenia bulletin · 2010Article
- FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies.BMC medical genetics · 2010Article
- Relating schizotypy and personality to the phenomenology of creativity.Schizophrenia bulletin · 2010Article
- Schizophrenia pathophysiology: are we any closer to a complete model?Annals of general psychiatry · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The evolutionary origins of one of the most dramatic and seemingly deleterious behavioral phenotypes, the syndrome known as schizophrenia, are mysterious. Schizophrenia occurs in all cultures and is inherited. Although most phenotypes are said to be "selected for" based on adaptive qualities, it is difficult to understand how the genetic basis of schizophrenia could have operated under a similar framework. This has lead several theorists analyzing the proposed evolutionary origins of other disease states to that of schizophrenia. To date, several models have been applied. We have tried to conceptualize schizophrenia in a compensatory advantage framework whereby incomplete penetrance of the full disorder, or alternatively, the inheritance of risk alleles insufficient in number to manifest as the classic clinical syndrome, may manifest as a behavioral phenotype with adaptive advantages (eg, creative behavior or novel illuminating ideas). The idea that even full penetrance can also be advantageous has been offered as applied to religious experience and ancient social standing, but is unlikely. Can complex behavioral phenotypes such as schizophrenia, and particularly those that seem purely deleterious, be explained by mechanisms of Darwinian psychiatry? Can models from other disease classes be applied successfully to schizophrenia? Such ideas have generated intense speculation, but often in the absence of testable models. In this article, we will examine some of these proposed ideas and offer suggestions for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.