ArticleJournal of the American Society of Nephrology : JASN2008
DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins.
Article in Journal of the American Society of Nephrology : JASN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 75 citations in OpenAlex.
- The role of long-term hair steroids as diagnostic and intervention-related biomarkers in a multimorbid inpatient sample with posttraumatic stress disorder.European journal of psychotraumatology · 2025Trial
- Sex differences in clinical and metabolic outcomes of glucocorticoid replacement therapy in adrenal insufficiency.Pituitary · 2026Review
- From womb to words: the sex-specific interplay of fetal sex hormones and maternal mood on infant language development.Frontiers in endocrinology · 2026Article
- Alterations in glucocorticoid homeostasis following sleeve gastrectomy.bioRxiv : the preprint server for biology · 2025Article
- E-Cigarette Smoke Exposure Elevates Renal MR Expression and Induces BP Elevation.Hypertension (Dallas, Tex. : 1979) · 2025Article
- DHEA: a neglected biological signal that may affect fetal and child development.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Thiram, an inhibitor of 11ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway.BMC pharmacology & toxicology · 2023Article
- Article
- Decreased 11β-Hydroxysteroid Dehydrogenase Type 2 Expression in the Kidney May Contribute to Nicotine/Smoking-Induced Blood Pressure Elevation in Mice.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood.Journal of the Endocrine Society · 2020Article
- Pubertal recalibration of cortisol-DHEA coupling in previously-institutionalized children.Hormones and behavior · 2020Article
- Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion.Scientific reports · 2019Article
- Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive NaFrontiers in physiology · 2019Article
- Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?Journal of neuroinflammation · 2018Review
- Programming for increased expression of hippocampal GAD67 mediated the hypersensitivity of the hypothalamic-pituitary-adrenal axis in male offspring rats with prenatal ethanol exposure.Cell death & disease · 2018Article
- Fructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome.Nutrients · 2017Review
- The activity of 11β-hydroxysteroid dehydrogenase type 2 enzyme and cortisol secretion in patients with adrenal incidentalomas.Endocrine · 2016Article
- Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.Pflugers Archiv : European journal of physiology · 2016Article
- Article
- Variants of 11β-hydroxysteroid dehydrogenase (HSD11B) gene type 1 and 2 in Chinese obese adolescents.Journal of endocrinological investigation · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
11beta-Hydroxysteroid dehydrogenase (11beta-HSD) type 1 and type 2 catalyze the interconversion of inactive and active glucocorticoids. Impaired regulation of these enzymes has been associated with obesity, diabetes, hypertension, and cardiovascular disease. Previous studies in animals and humans suggested that dehydroepiandrosterone (DHEA) has antiglucocorticoid effects, but the underlying mechanisms are unknown. In this study, DHEA treatment markedly increased mRNA expression and activity of 11beta-HSD2 in a rat cortical collecting duct cell line and in kidneys of C57BL/6J mice and Sprague-Dawley rats. DHEA-treated rats tended to have reduced urinary corticosterone to 11-dehydrocorticosterone ratios. It was found that CCAAT/enhancer-binding protein-alpha (C/EBP-alpha) and C/EBP-beta regulated HSD11B2 transcription and that DHEA likely modulated the transcription of 11beta-HSD2 in a phosphatidylinositol-3 kinase/Akt-dependent manner by increasing C/EBP-beta mRNA and protein expression. Moreover, it is shown that C/EBP-alpha and C/EBP-beta differentially regulate the expression of 11beta-HSD1 and 11beta-HSD2. In conclusion, DHEA induces a shift from 11beta-HSD1 to 11beta-HSD2 expression, increasing conversion from active to inactive glucocorticoids. This provides a possible explanation for the antiglucocorticoid effects of DHEA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.