ArticleGenome research2008
The genome-wide determinants of human and chimpanzee microsatellite evolution.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
132 citing papers in PubMed, 285 citations in OpenAlex.
- Mitochondrial Genome Characteristics ofEcology and evolution · 2026Article
- A family portrait of the genomic factors shaping tandem repeat mutagenesis.bioRxiv : the preprint server for biology · 2026Article
- Genetic diversity and breeding efficiency of a salt-tolerant strain of largemouth bass (Micropterus salmoides) revealed by microsatellite analysis and phenotypic evaluations.Scientific reports · 2026Article
- Article
- Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths.Nature communications · 2025Article
- Genome-wide selection inference at short tandem repeats.PLoS genetics · 2025Article
- Genome-Wide Microsatellite Characterization and Molecular Marker Development of Himalayan Griffon (Animals : an open access journal from MDPI · 2025Article
- A detailed analysis of second and third-generation sequencing approaches for accurate length determination of short tandem repeats and homopolymers.Nucleic acids research · 2025Article
- Fitness landscapes of human microsatellites.PLoS genetics · 2024Article
- Molecular Characterization and Phylogenetic Analysis of Centipedegrass [Current issues in molecular biology · 2024Article
- Development and Application of Potentially Universal Microsatellite Markers for Pheasant Species.Animals : an open access journal from MDPI · 2023Article
- Article
- Sequence variants affecting the genome-wide rate of germline microsatellite mutations.Nature communications · 2023Article
- Analysis of genome instability and implications for the consequent phenotype inMicrobial genomics · 2023Article
- Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species.Journal of evolutionary biology · 2023Review
- Article
- Genomic microsatellite characteristics analysis ofBiodiversity data journal · 2023Article
- A comparative study of population genetic structure reveals patterns consistent with selection at functional microsatellites in common sunflower.Molecular genetics and genomics : MGG · 2022Article
- Genome-wideGene reports · 2021Article
- Whole genome survey and microsatellite motif identification of Artemia franciscana.Bioscience reports · 2021Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mutation rates of microsatellites vary greatly among loci. The causes of this heterogeneity remain largely enigmatic yet are crucial for understanding numerous human neurological diseases and genetic instability in cancer. In this first genome-wide study, the relative contributions of intrinsic features and regional genomic factors to the variation in mutability among orthologous human-chimpanzee microsatellites are investigated with resampling and regression techniques. As a result, we uncover the intricacies of microsatellite mutagenesis as follows. First, intrinsic features (repeat number, length, and motif size), which all influence the probability and rate of slippage, are the strongest predictors of mutability. Second, mutability increases nonuniformly with length, suggesting that processes additional to slippage, such as faulty repair, contribute to mutations. Third, mutability varies among microsatellites with different motif composition likely due to dissimilarities in secondary DNA structure formed by their slippage intermediates. Fourth, mutability of mononucleotide microsatellites is impacted by their location on sex chromosomes vs. autosomes and inside vs. outside of Alu repeats, the former confirming the importance of replication and the latter suggesting a role for gene conversion. Fifth, transcription status and location in a particular isochore do not influence microsatellite mutability. Sixth, compared with intrinsic features, regional genomic factors have only minor effects. Finally, our regression models explain approximately 90% of variation in microsatellite mutability and can generate useful predictions for the studies of human diseases, forensics, and conservation genetics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.