ArticleBlood2008
Indirect involvement of allergen-captured mast cells in antigen presentation.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- To Investigate the Involvement of Mast Cells in the Pathogenesis of Oral Lichen Planus and Oral Lichenoid Reactions.Journal of pharmacy & bioallied sciences · 2024Article
- Conventional and non-conventional antigen presentation by mast cells.Discovery immunology · 2023Review
- Microarray patches enable the development of skin-targeted vaccines against COVID-19.Advanced drug delivery reviews · 2021Review
- IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?Antibodies (Basel, Switzerland) · 2020Review
- Professional and 'Amateur' Antigen-Presenting Cells In Type 2 Immunity.Trends in immunology · 2019Review
- Meningeal mast cell-T cell crosstalk regulates T cell encephalitogenicity.Journal of autoimmunity · 2016Article
- Roles and relevance of mast cells in infection and vaccination.Journal of biomedical research · 2016Review
- Antigen/IgG immune complex-primed mucosal mast cells mediate antigen-specific activation of co-cultured T cells.Immunology · 2015Article
- Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?Nature reviews. Immunology · 2014Review
- Mast Cells are Important Modifiers of Autoimmune Disease: With so Much Evidence, Why is There Still Controversy?Frontiers in immunology · 2012Article
- Cellular therapies supplement: the role of granulocyte macrophage colony-stimulating factor and dendritic cells in regulatory T-cell homeostasis and expansion.Transfusion · 2011Article
- Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection.Parasite immunology · 2011Article
- Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.Molecular and cellular biology · 2010Article
- Programming dendritic cells to induce T(H)2 and tolerogenic responses.Nature immunology · 2010Review
- MHC class II expression by mast cells in the genital tract of cows.Veterinary research communications · 2010Article
- Cognate interactions between mast cells and helper T lymphocytes.Self/nonself · 2010Article
- Signaling pathways critical for allergic airway inflammation.Current opinion in allergy and clinical immunology · 2010Review
- Review
- Mast cell modulation of the immune response.Current allergy and asthma reports · 2009Review
- Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response.Nature immunology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
It is generally thought that mast cells influence T-cell activation nonspecifically through the release of inflammatory mediators. In this report, we provide evidence that mast cells may also affect antigen-specific T-cell responses by internalizing immunoglobulin E-bound antigens for presentation to antigen-specific T cells. Surprisingly, T-cell activation did not require that mast cells express major histocompatibility complex class II, indicating that mast cells were not involved in the direct presentation of the internalized antigens. Rather, the antigen captured by mast cells is presented by other major histocompatibility complex class II(+) antigen-presenting cells. To explore how this may occur, we investigated the fate of mast cells stimulated by antigen and found that FcepsilonRI crosslinking enhances mast cell apoptosis. Cell death by antigen-captured mast cells was required for efficient presentation because protection of mast cell death significantly decreased T-cell activation. These results suggest that mast cells may be involved in antigen presentation by acting as an antigen reservoir after antigen capture through specific immunoglobulin E molecules bound to their FcepsilonRI. This mechanism may contribute to how mast cells impact the development of T-cell responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.