ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Resonant or not, two amplification modes of proprioceptive inputs by persistent inward currents in spinal motoneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Machine-learning classification of motor unit types in the adult mouse.The Journal of physiology · 2026Article
- Ia excitatory postsynaptic potentials are potentiated in slow-type motoneurons after a 5-week treadmill endurance training in rats.European journal of applied physiology · 2026Article
- Increase in Ia Afferent Synaptic Excitation of SOD1 G93A Mouse Motoneurons by 2-Week Anodal Trans-Spinal Direct Current Stimulation Does Not Ameliorate the Cellular Burden of the Disease.The European journal of neuroscience · 2025Article
- Machine-Learning Classification of Motor Unit Types in the Adult Mouse.bioRxiv : the preprint server for biology · 2025Article
- Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents: A simulation study.PLoS computational biology · 2024Article
- Recruitment of Motoneurons.Advances in neurobiology · 2022Article
- Diversity of Mammalian Motoneurons and Motor Units.Advances in neurobiology · 2022Article
- Location, location, location: the organization and roles of potassium channels in mammalian motoneurons.The Journal of physiology · 2021Article
- Effective Stimulation Type and Waveform for Force Control of the Motor Unit System: Implications for Intraspinal Microstimulation.Frontiers in neuroscience · 2021Article
- Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS.The Journal of experimental medicine · 2020Article
- Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The role of negative conductances in neuronal subthreshold properties and synaptic integration.Biophysical reviews · 2017Review
- PICs in motoneurons do not scale with the size of the animal: a possible mechanism for faster speed of muscle contraction in smaller species.Journal of neurophysiology · 2017Article
- Synaptic control of the shape of the motoneuron pool input-output function.Journal of neurophysiology · 2017Article
- Contributions of motoneuron hyperexcitability to clinical spasticity in hemispheric stroke survivors.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2015Article
- Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study.Journal of neurophysiology · 2015Article
- Frequency-dependent amplification of stretch-evoked excitatory input in spinal motoneurons.Journal of neurophysiology · 2012Article
- Contribution of intrinsic properties and synaptic inputs to motoneuron discharge patterns: a simulation study.Journal of neurophysiology · 2012Article
- Adult mouse motor units develop almost all of their force in the subprimary range: a new all-or-none strategy for force recruitment?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Effects of persistent inward currents, accommodation, and adaptation on motor unit behavior: a simulation study.Journal of neurophysiology · 2011Article
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Authors and funding
4 authors.
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Abstract
Why do motoneurons possess two persistent inward currents (PICs), a fast sodium current and a slow calcium current? To answer this question, we replaced the natural PICs with dynamic clamp-imposed artificial PICs at the soma of spinal motoneurons of anesthetized cats. We investigated how PICs with different kinetics (1-100 ms) amplify proprioceptive inputs. We showed that their action depends on the presence or absence of a resonance created by the I(h) current. In resonant motoneurons, a fast PIC enhances the resonance and amplifies the dynamic component of Ia inputs elicited by ramp-and-hold muscle stretches. This facilitates the recruitment of these motoneurons, which likely innervate fast contracting motor units developing large forces, e.g., to restore balance or produce ballistic movements. In nonresonant motoneurons, in contrast, a fast PIC easily triggers plateau potentials, which leads to a dramatic amplification of the static component of Ia inputs. This likely facilitates the recruitment of these motoneurons, innervating mostly slowly contracting and fatigue-resistant motor units, during postural activities. Finally, a slow PIC may switch a resonant motoneuron to nonresonant by counterbalancing I(h), thus changing the action of the fast PIC. A modeling study shows that I(h) needs to be located on the dendrites to create the resonance, and it predicts that dendritic PICs amplify synaptic input in the same manner as somatic PICs.
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