ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Non-cell-autonomous regulation of GABAergic neuron development by neurotrophins and the p75 receptor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Acetylcholine regulation of GnRH neuronal activity: A circuit in the medial septum.Frontiers in endocrinology · 2023Article
- All-trans retinoic acid induces reprogramming of canine dedifferentiated cells into neuron-like cells.PloS one · 2020Article
- New GABAergic Neurogenesis in the Hippocampal CA1 Region of a Gerbil Model of Long-Term Survival after Transient Cerebral Ischemic Injury.Brain pathology (Zurich, Switzerland) · 2016Article
- Crosstalk among electrical activity, trophic factors and morphogenetic proteins in the regulation of neurotransmitter phenotype specification.Journal of chemical neuroanatomy · 2016Review
- Interplay of environmental signals and progenitor diversity on fate specification of cortical GABAergic neurons.Frontiers in cellular neuroscience · 2015Review
- Effects of sustained proNGF blockade on attentional capacities in aged rats with compromised cholinergic system.Neuroscience · 2014Article
- Dynamic regulation of neurotransmitter specification: relevance to nervous system homeostasis.Neuropharmacology · 2014Review
- NMDA-dependent switch of proBDNF actions on developing GABAergic synapses.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Induction of the GABA cell phenotype: an in vitro model for studying neurodevelopmental disorders.PloS one · 2012Article
- Genetically induced cholinergic hyper-innervation enhances taste learning.Frontiers in systems neuroscience · 2011Article
- BMP9 (bone morphogenetic protein 9) induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatum.Stem cells (Dayton, Ohio) · 2009Article
- Differential modulation of nerve growth factor receptor (p75) and cholinergic gene expression in purified p75-expressing and non-expressing basal forebrain neurons by BMP9.Brain research · 2008Article
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4 authors at 1 institution in 1 country.
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Abstract
Basal forebrain GABAergic and cholinergic circuits regulate the activity of cholinergic projections to the cortex and hippocampus. Because these projections influence cortical development and function, the development of basal forebrain excitatory and inhibitory neurons is critical for overall brain development. We show that the neurotransmitter phenotype of these neurons is developmentally regulated by neurotrophins and the p75 receptor. Neurotrophins (nerve growth factor and brain-derived neurotrophic factor) increased the number of both cholinergic and GABAergic neurons in neonatal basal forebrain neuron cultures from the region of the medial septum. However, the p75 receptor is required only for neurotrophin-dependent expansion of the GABAergic, not the cholinergic, population. Neurotrophin-induced GABAergic development can be rescued in p75-/- cultures by expression of a p75 rescue construct in neighboring cells or by treatment with medium collected from neurotrophin-treated wild-type cultures. Because p75 is not expressed in basal forebrain GABAergic neurons, this defines a new, non-cell-autonomous mechanism of p75 action in which ligand binding results in release of a soluble factor that modifies neurotrophin responses of nearby neurons. p75 is also required for the maintenance of basal forebrain GABAergic neurons in vivo, demonstrating that p75-mediated interactions between cholinergic and GABAergic neurons regulate the balance of excitatory and inhibitory components of basal forebrain circuits.
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