ArticleJournal of clinical microbiology2008
Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing.
Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Burkholderia multivorans Infections Associated with Use of Ice and Water from Ice Machines for Patient Care Activities - Four Hospitals, California and Colorado, 2020-2024.MMWR. Morbidity and mortality weekly report · 2024Article
- Identification of two distinct phylogenomic lineages and model strains for the understudied cystic fibrosis lung pathogenMicrobiology (Reading, England) · 2023Article
- Phylogenetic Characterization and Genome Sequence Analysis ofPathogens (Basel, Switzerland) · 2022Article
- Burkholderia species in human infections in Mexico: Identification of B. cepacia, B. contaminans, B. multivorans, B. vietnamiensis,B. pseudomallei and a new Burkholderia species.PLoS neglected tropical diseases · 2021Article
- Genomics reveals the novel species placement of industrial contaminant isolates incorrectly identified asMicrobial genomics · 2021Article
- Genomics of an endemic cystic fibrosis Burkholderia multivorans strain reveals low within-patient evolution but high between-patient diversity.PLoS pathogens · 2021Article
- Microbiology of Cystic Fibrosis Airway Disease.Seminars in respiratory and critical care medicine · 2019Review
- Whole Genome Sequence Analysis of Burkholderia contaminans FFH2055 Strain Reveals the Presence of Putative β-Lactamases.Current microbiology · 2019Article
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- Comparative genomics of Burkholderia multivorans, a ubiquitous pathogen with a highly conserved genomic structure.PloS one · 2017Article
- PCR detection of Burkholderia multivorans in water and soil samples.BMC microbiology · 2016Article
- Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection.Infection and immunity · 2016Article
- Development of a multiple-locus variable-number tandem-repeat typing scheme for genetic fingerprinting of Burkholderia cenocepacia and application to nationwide epidemiological analysis.Journal of clinical microbiology · 2015Article
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- Inhibition of Burkholderia multivorans adhesion to lung epithelial cells by bivalent lactosides.Molecules (Basel, Switzerland) · 2012Article
- Comparative analysis of two phenotypically-similar but genomically-distinct Burkholderia cenocepacia-specific bacteriophages.BMC genomics · 2012Article
- Diversity analysis of Burkholderia cepacia complex in the water bodies of West Lake, Hangzhou, China.Journal of microbiology (Seoul, Korea) · 2011Article
- Can early Burkholderia cepacia complex infection in cystic fibrosis be eradicated with antibiotic therapy?Frontiers in cellular and infection microbiology · 2011Article
- A decade of Burkholderia cenocepacia virulence determinant research.Infection and immunity · 2010Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 5 countries.
Funding
Abstract
Burkholderia multivorans is a prominent B. cepacia complex (BCC) species causing infection in people with cystic fibrosis. Despite infection control measures being introduced to reduce the spread of BCC there is a continued emergence of infections by B. multivorans. Our objective was to analyze a global collection of B. multivorans isolates, comparing those from environmental and clinical sources with those from reported outbreaks. Multilocus sequence typing (MLST) was performed on 107 B. multivorans isolates to provide a detailed analysis of the global population biology of this species. MLST resolved 64 B. multivorans sequence types. Twelve of these were globally distributed and associated with human infection; two of these (ST-21 and ST-375) were also composed of environmental isolates. These global lineages included strains previously linked to large outbreaks (e.g., French epidemic clone ST-16). Though few environmental isolates of B. multivorans were available for analysis, of six strains identified, three were identical to strains recovered from cystic fibrosis (CF) infection. Although the ability of B. multivorans to cause CF outbreaks is known, our report here concerning the existence of globally distributed B. multivorans CF strains is a new observation for this emerging B. cepacia complex pathogen and suggests that certain strain types may be better adapted to human infection than others. Common transmission-associated risk factors were not obviously linked to the globally distributed strains; however, the overlap in strains recovered from water environments, industrial products, and human infection suggests that environmental sources may be an important reservoir for infection with B. multivorans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.