Trial reportBiological psychology2008
Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals.
Trial report in Biological psychology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Shared effects of the opioid antagonist naltrexone on first-hand and empathic pain.Social cognitive and affective neuroscience · 2026Trial
- Stress and pain: modality-specific opioid mediation of stress-induced analgesia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Trial
- Hypoalgesia associated with elevated resting blood pressure: evidence for endogenous opioid involvement.Journal of behavioral medicine · 2010Trial
- Effects of opioid blockade on nociceptive flexion reflex thresholds and nociceptive responding in hypertensive and normotensive individuals.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2008Trial
- Prevalence of pain in community-dwelling older adults with hypertension in the United States.Scientific reports · 2022Article
- Hypertension meets osteoarthritis - revisiting the vascular aetiology hypothesis.Nature reviews. Rheumatology · 2021Review
- Dissociation between reduced pain and arterial blood pressure following epidural spinal cord stimulation in patients with chronic pain: A retrospective study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Anxiety, Depression, and Pain: Considerations in the Treatment of Patients with Uncontrolled Hypertension.Current hypertension reports · 2020Review
- Hypertension and Postoperative Pain: A Prospective Observational Study.Pain research & management · 2019Observational
- Stress and Addiction: When a Robust Stress Response Indicates Resiliency.Psychosomatic medicine · 2018Review
- The relationship between blood pressure and pain.Journal of clinical hypertension (Greenwich, Conn.) · 2013Review
- Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension.Biological psychology · 2007Article
- Hypertension and pain: A state-based framework for cardiovascular-nociceptive coupling.Neurobiology of pain (Cambridge, Mass.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.