ArticleSurgery today2007
Lymph node micrometastasis: a predictor of early tumor relapse after complete resection of histologically node-negative esophageal cancer.
Article in Surgery today, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Association Between Metastatic Pattern and Prognosis in Stage IV Gastric Cancer: Potential for Stage Classification Reform.Annals of surgical oncology · 2023Article
- Histological prognosticators in neoadjuvant naive oesophageal cancer patients.Langenbeck's archives of surgery · 2023Article
- Nonregional Lymph Nodes as the Only Metastatic Site in Stage IV Esophageal Cancer.JTO clinical and research reports · 2022Article
- The Least Nodal Disease Burden Defines the Minimum Number of Nodes Retrieved for Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Prognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma.Scientific reports · 2020Article
- Sentinel node navigation surgery in esophageal cancer.Annals of gastroenterological surgery · 2019Review
- The presence of lymphovascular and perineural infiltration after neoadjuvant therapy and oesophagectomy identifies patients at high risk for recurrence.British journal of cancer · 2015Article
- Clinical study on postoperative recurrence in patients with pN0 esophageal squamous cell carcinoma.Journal of cardiothoracic surgery · 2014Article
- Micrometastasis of hypopharyngeal cancer.Langenbeck's archives of surgery · 2014Article
- Lymph node micrometastasis in gastrointestinal tract cancer--a clinical aspect.International journal of clinical oncology · 2013Review
- USP22 nuclear expression is significantly associated with progression and unfavorable clinical outcome in human esophageal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2012Article
- Mucin 1 and vascular endothelial growth factor C expression correlates with lymph node metastatic recurrence in patients with N0 esophageal cancer after Ivor-Lewis esophagectomy.World journal of surgery · 2011Article
- Impact of perioperative peripheral blood values on postoperative complications after esophageal surgery.Surgery today · 2010Article
- Metastasis-associated protein 1 (MTA1) overexpression is closely associated with shorter disease-free interval after complete resection of histologically node-negative esophageal cancer.World journal of surgery · 2009Article
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Authors and funding
6 authors.
Funding
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Abstract
purposeTo investigate the prevalence of lymph node micrometastasis (LNMM) on the basis of the detection of MUC1 mRNA, and assess the impact of these micrometastases on disease-free interval after resection of pathologic N0 (pN0) esophageal squamous cell cancer (ESCC).
methodsThe subjects were 93 patients who underwent complete resection of pN0 ESCC at our department between January 1999 and January 2001. All lymph nodes (426 stations) obtained from these patients were reevaluated by reverse transcription-polymerase chain reaction to detect MUC1 mRNA. The diagnosis of LNMM was based on the detection of MUC1 mRNA. A log-rank test was performed to compare the disease-free interval, and Cox regression multivariate analysis was performed to determine the independent prognostic factors.
resultsMicrometastasis was detected in 40 lymph node stations (9.4%) from 32 patients (34.4%). Disease-free interval was significantly associated with LNMM (P = 0.0138). The 5-year survival rate of patients with LNMM was significantly lower than that of those without LNMM (P = 0.004). The results of multivariate analysis confirmed that T status and LNMM were independent prognostic factors.
conclusionsThe prevalence of LNMM in patients with pN0 ESCC was 34.4% (32/93). Thus, LNMM was significantly associated with the disease-free interval. T status and LNMM were both independent prognostic factors.
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