ArticlePloS one2007
Microarray expression profiles of 20.000 genes across 23 healthy porcine tissues.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- A transcriptional landscape of 28 porcine tissues obtained by super deepSAGE sequencing.BMC genomics · 2020Article
- Origin and Evolution of H1N1/pdm2009: A Codon Usage Perspective.Frontiers in microbiology · 2020Article
- Molecular approaches to the diagnosis and monitoring of production diseases in pigs.Research in veterinary science · 2017Review
- Genome-wide analysis of DNA methylation in pigs using reduced representation bisulfite sequencing.DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
- The Longissimus and Semimembranosus muscles display marked differences in their gene expression profiles in pig.PloS one · 2014Article
- BioGPS and GXD: mouse gene expression data-the benefits and challenges of data integration.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Oligonucleotide microarray analysis of dietary-induced hyperlipidemia gene expression profiles in miniature pigs.PloS one · 2012Article
- A global view of porcine transcriptome in three tissues from a full-sib pair with extreme phenotypes in growth and fat deposition by paired-end RNA sequencing.BMC genomics · 2011Article
- Expression cartography of human tissues using self organizing maps.BMC bioinformatics · 2011Article
- A compendium of canine normal tissue gene expression.PloS one · 2011Article
- Oligonucleotide microarray analysis of age-related gene expression profiles in miniature pigs.PloS one · 2011Article
- The adult boar testicular and epididymal transcriptomes.BMC genomics · 2009Article
- Transcriptomic and proteomic profiling of two porcine tissues using high-throughput technologies.BMC genomics · 2009Article
- Gene expression profiles in liver of pigs with extreme high and low levels of androstenone.BMC veterinary research · 2008Article
- Characterization of a newly developed chicken 44K Agilent microarray.BMC genomics · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGene expression microarrays have been intensively applied to screen for genes involved in specific biological processes of interest such as diseases or responses to environmental stimuli. For mammalian species, cataloging of the global gene expression profiles in large tissue collections under normal conditions have been focusing on human and mouse genomes but is lacking for the pig genome. METHODOLOGY/PRINCIPAL
findingsHere we present the results from a large-scale porcine study establishing microarray cDNA expression profiles of approximately 20.000 genes across 23 healthy tissues. As expected, a large portion of the genes show tissue specific expression in agreement with mappings to gene descriptions, Gene Ontology terms and KEGG pathways. Two-way hierarchical clustering identified expected tissue clusters in accordance with tissue type and a number of cDNA clusters having similar gene expression patterns across tissues. For one of these cDNA clusters, we demonstrate that possible tissue associated gene function can be inferred for previously uncharacterized genes based on their shared expression patterns with functionally annotated genes. We show that gene expression in common porcine tissues is similar to the expression in homologous tissues of human. CONCLUSIONS/SIGNIFICANCE: The results from this study constitute a valuable and publicly available resource of basic gene expression profiles in normal porcine tissues and will contribute to the identification and functional annotation of porcine genes.
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