ArticleBlood2008
The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 84 citations in OpenAlex.
- Network Pharmacology and Transcriptomic Analysis Reveal the Therapeutic Mechanisms of Xiebai Bining Decoction in Hyperuricemic Nephropathy.Combinatorial chemistry & high throughput screening · 2026Article
- Protective role of gout against colorectal cancer: a Mendelian randomization study.Discover oncology · 2025Article
- Hyperuricemia is accompanied by elevated peripheral CD4Scientific reports · 2023Article
- Comparative analysis of clinical and imaging data between patients with myelin oligodendrocyte glycoprotein antibody disease and patients with aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder.Journal of neurology · 2022Article
- Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-β-activated kinase 1.Oncoimmunology · 2022Article
- Article
- Male asymptomatic hyperuricemia patients display a lower number of NKG2D+ NK cells before and after a low-purine diet.Medicine · 2018Article
- The inflammation paradox: Why are Tsimane protected against Western diseases while Westerners are not?F1000Research · 2018Observational
- Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout.Protein & cell · 2017Article
- Elevated cerebrospinal fluid uric acid during relapse of neuromyelitis optica spectrum disorders.Brain and behavior · 2017Article
- Biological Activities of Uric Acid in Infection Due to Enteropathogenic and Shiga-Toxigenic Escherichia coli.Infection and immunity · 2016Article
- PD-1 Blunts the Function of Ovarian Tumor-Infiltrating Dendritic Cells by Inactivating NF-κB.Cancer research · 2016Article
- Uric acid enhances the antitumor immunity of dendritic cell-based vaccine.Scientific reports · 2015Article
- Danger signalling during cancer cell death: origins, plasticity and regulation.Cell death and differentiation · 2014Review
- Pro-inflammatory effects of uric acid in the gastrointestinal tract.Immunological investigations · 2014Article
- Uric acid: A hypothetical cause of preeclampsia-eclampsia.Nigerian medical journal : journal of the Nigeria Medical Association · 2013Article
- Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects.International reviews of immunology · 2013Review
- Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans.PloS one · 2013Article
- Type II NKT cells facilitate Alum-sensing and humoral immunity.Journal of leukocyte biology · 2012Article
- Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis.Cellular & molecular immunology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Studies have shown that the immune system can recognize self-antigens under conditions (eg, cell injury) in which the self-tissue might elaborate immune-activating endogenous danger signals. Uric acid (UA) is an endogenous danger signal recently identified to be released from dying cells. Prior work has shown that UA activates immune effectors of both the innate and adaptive immune system, including neutrophils and cytotoxic T-cell immunity. However, it was unclear whether UA could enhance antibody immunity, which was examined in this study. When added to dying tumor cells or with whole protein antigen, UA increased IgG1-based humoral immunity. Further, UA blocked growth of tumor in subsequent tumor challenge experiments, which depended on CD4, but not CD8, T cells. Sera derived from UA-treated animals enhanced tumor growth, suggesting it had little role in the antitumor response. UA did not signal for T-cell expansion or altered tumor-infiltrating leukocyte populations. Consistent with the lack of T-cell expansion, when applied to dendritic cells, UA suppressed T-cell growth factors but up-regulated B cell-activating cytokines. Understanding the nature of endogenous danger signals released from dying cells may aid in a better understanding of mechanisms of immune recognition of self.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.