ArticleThe Journal of clinical endocrinology and metabolism2008
Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men.
Article in The Journal of clinical endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01761318 (Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Profiling of Endogenous and Gut Microbial Metabolites to Indicate Metabotype-Specific Dietary Responses: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Effects of short-term hypercaloric nutrition on orthostatic tolerance in healthy individuals: a randomized controlled crossover study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Trial
- HFpEF and MASLD: converging mechanisms and clinical implications.Nature reviews. Cardiology · 2026Review
- The carrying capacity for free fatty acids in plasma is exceedingly high in mammals, and this may be a liability for human metabolic health.The Journal of physiology · 2026Article
- Metabolic dysfunction-associated steatotic liver disease and heart failure with preserved ejection fraction: A state-of-the-art review.World journal of cardiology · 2026Review
- Impact of long-term fasting on liver and abdominal adipose tissues monitored by quantitative chemical-shift encoded MRI.Frontiers in nutrition · 2026Article
- Lipidomics Reveals Myocardial Lipid Composition in a Murine Model of Insulin Resistance Induced by a High-Fat Diet.International journal of molecular sciences · 2024Article
- Myocardial steatosis across the spectrum of human health and disease.Experimental physiology · 2024Review
- Myocardial steatosis impairs left ventricular diastolic-systolic coupling in healthy humans.The Journal of physiology · 2023Article
- Diabetes Mellitus and Heart Failure: Epidemiology, Pathophysiologic Mechanisms, and the Role of SGLT2 Inhibitors.Life (Basel, Switzerland) · 2023Review
- Is increased myocardial triglyceride content associated with early changes in left ventricular function? AFrontiers in endocrinology · 2023Article
- Long-term fasting: Multi-system adaptations in humans (GENESIS) study-A single-arm interventional trial.Frontiers in nutrition · 2022Article
- Lipotoxicity: a driver of heart failure with preserved ejection fraction?Clinical science (London, England : 1979) · 2021Review
- Comparison of single-voxelJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities.Basic research in cardiology · 2020Review
- Acute intramyocardial lipid accumulation in rats does not slow cardiac conduction per se.Physiological reports · 2019Article
- Mitochondrial NADAntioxidants & redox signaling · 2019Review
- Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture.Frontiers in physiology · 2019Review
- Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology.European heart journal · 2018Article
- Opposing effects on cardiac function by calorie restriction in different-aged mice.Aging cell · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextIn animal experiments, high plasma concentrations of free fatty acids (FFAs) are associated with increased triglyceride (TG) stores in liver and heart, and impaired cardiac function. In humans caloric restriction increases plasma FFA levels.
objectiveOur objective was to assess the effects of progressive caloric restriction on myocardial and hepatic TG content and myocardial function.
designThis was a prospective intervention study.
participantsThis study included 10 lean healthy men.
interventionsThree-day partial (471 kcal/d) and complete starvation was performed. OUTCOME MEASURES: Plasma levels of FFA, myocardial and hepatic TG content, and myocardial function were calculated.
resultsPlasma FFA increased from 0.6 +/- 0.4 mmol/liter to 1.2 +/- 0.4 and to 1.9 +/- 0.7 mmol/liter, after partial and complete starvation, respectively (P < 0.001). Myocardial TG content increased from 0.35 +/- 0.14% to 0.59 +/- 0.27%, and 1.26 +/- 0.49%, respectively (P < 0.01). The ratio between the early diastole and atrial contraction decreased from 2.2 +/- 0.4 to 2.1 +/- 0.4 (P = 0.7) and 1.8 +/- 0.4, respectively (P < 0.01), and diastolic early deceleration from 3.4 +/- 0.7 ml/sec(2) x 10(-3) to 2.9 +/- 0.5 and 2.8 +/- 0.9 ml/sec(2) x 10(-3), respectively (P < 0.05). Hepatic TG content decreased after partial starvation (from 2.23 +/- 2.24% to 1.43 +/- 1.33%; P < 0.05) but did not change upon complete starvation.
conclusionsProgressive caloric restriction induces a dose-dependent increase in myocardial TG content and a dose-dependent decrease in diastolic function in lean healthy men. Hepatic TG content showed a differential response to progressive caloric restriction, indicating that redistribution of endogenous TG stores is tissue specific.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.