ReviewCurrent opinion in pharmacology2007
Role of visceral afferent neurons in mucosal inflammation and defense.
Review in Current opinion in pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Acute Severe Pancolitis After Initiation of a Calcitonin Gene-Related Peptide Receptor Antagonist: A Case Report.ACG case reports journal · 2026Article
- The TMEM63B Channel Facilitates Intestinal Motility and Enhances Proliferation of Intestinal Stem Cells.Cells · 2024Article
- Article
- Crosstalk Between the Nervous System and Systemic Organs in Acute Brain Injury.Neurocritical care · 2024Review
- Understanding the role of nerves in head and neck cancers - a review.Oncology reviews · 2024Review
- CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023Review
- The enteric nervous system.Physiological reviews · 2023Review
- Topographical organization and morphology of substance P (SP)-immunoreactive axons in the whole stomach of mice.The Journal of comparative neurology · 2023Article
- Review
- Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury.The Journal of clinical investigation · 2021Review
- Nitrergic and Substance P Immunoreactive Neurons in the Enteric Nervous System of the Bottlenose Dolphin (Animals : an open access journal from MDPI · 2021Article
- Pathophysiological Bases of Comorbidity in Migraine.Frontiers in human neuroscience · 2021Review
- Article
- Mycotoxins and the Enteric Nervous System.Toxins · 2020Review
- Article
- Curcumin: A Potent Protectant against Esophageal and Gastric Disorders.International journal of molecular sciences · 2019Review
- Bioelectric neuromodulation for gastrointestinal disorders: effectiveness and mechanisms.Nature reviews. Gastroenterology & hepatology · 2019Review
- TRPA1 and substance P mediate stress induced duodenal lesions in water immersion restraint stress rat model.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- Effects of Oxaliplatin Treatment on the Myenteric Plexus Innervation and Glia in the Murine Distal Colon.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells.Immunity · 2018Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The maintenance of gastrointestinal (GI) mucosal integrity depends on the rapid alarm of protective mechanisms in the face of pending injury. Two populations of extrinsic primary afferent neurons, vagal and spinal, subserve this goal through different mechanisms. These sensory neurons react to GI insults by triggering protective autonomic reflexes including the so-called cholinergic anti-inflammatory reflex. Spinal afferents, in addition, can initiate protective tissue reactions at the site of assault through release of calcitonin gene-related peptide (CGRP) from their peripheral endings. The protective responses triggered by sensory neurons comprise alterations in GI blood flow, secretion, and motility as well as modifications of immune function. This article focuses on significant advances that during the past couple of years have been made in identifying molecular nocisensors on afferent neurons and in dissecting the signaling mechanisms whereby afferent neurons govern inflammatory processes in the gut.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.