ArticleDevelopmental biology2007
Developmental morphology and chemotactic responses are dependent on G alpha subunit specificity in Dictyostelium.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Related Dictyostelium G protein subunits Gα1 and Gα2 have different roles in chemotaxis and transcription factor regulation.BMC molecular and cell biology · 2025Article
- MAPK docking motif in the Dictyostelium Gα2 subunit is required for aggregation and transcription factor translocation.Cellular signalling · 2021Article
- Forty-five years of cGMP research inMolecular biology of the cell · 2021Review
- Mitogen-activated protein kinase regulation of the phosphodiesterase RegA in earlyMicrobiology (Reading, England) · 2020Article
- Dictyostelium Erk2 is an atypical MAPK required for chemotaxis.Cellular signalling · 2018Article
- G-Protein Dependent Signal Transduction and Ubiquitination in Dictyostelium.International journal of molecular sciences · 2017Review
- Article
- The Dictyostelium MAPK ERK1 is phosphorylated in a secondary response to early developmental signaling.Cellular signalling · 2015Article
- Loss of cAMP-specific phosphodiesterase rescues spore development in G protein mutant in dictyostelium.Cellular signalling · 2014Article
- Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses.Journal of cell science · 2013Article
- MAPKs in development: insights from Dictyostelium signaling pathways.Biomolecular concepts · 2011Article
- MAP kinases have different functions in Dictyostelium G protein-mediated signaling.Cellular signalling · 2010Article
- G{alpha}5 subunit-mediated signalling requires a D-motif and the MAPK ERK1 in Dictyostelium.Microbiology (Reading, England) · 2010Article
- Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity.Annual review of biophysics · 2010Review
- The Galpha4 G protein subunit interacts with the MAP kinase ERK2 using a D-motif that regulates developmental morphogenesis in Dictyostelium.Developmental biology · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Dictyostelium discoideum expresses multiple G alpha subunits but only a single G beta and G gamma subunit suggesting that the specific response to an external signal depends largely on G alpha subunit function or G protein-independent signaling from the receptor. To test the contribution of G alpha subunit functional specificity, the chimeric G alpha subunits, G alpha2/4 and G alpha5/4, were created and analyzed along with wild-type subunits for the ability to substitute for the G alpha4 subunit in mediating responses from folate receptors. The G alpha2/4 subunit, but not the G alpha2 or G alpha5/4 subunits, partly rescued chemotaxis and cGMP accumulation in folate-stimulated g alpha4(-) cells. Expression of the G alpha5/4 or G alpha5 subunits resulted in an inhibition of g alpha4- and wild-type cell movement and a reduced aggregate size in developing wild-type and g alpha5- cells suggesting these subunits mediate similar responses. Only the G alpha4 subunit was capable of correcting developmental morphology in g alpha4- multicellular aggregates suggesting that the chimeric G alpha2/4 or G alpha5/4 subunits were insufficient to provide the G alpha4 function necessary for proper development. These results indicate that Dictyostelium G alpha subunit specificity is not limited to receptor coupling and that G alpha subunit sequences outside of the carboxyl terminus are important for cell movement and developmental processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.