ArticleGenome biology2007
Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
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- Comparative transcriptomic rhythms in the mouse and human prefrontal cortex.Frontiers in neuroscience · 2024Article
- Sex Inclusion in Transcriptome Studies of Daily Rhythms.Journal of biological rhythms · 2023Article
- Paclitaxel chemotherapy disrupts behavioral and molecular circadian clocks in mice.Brain, behavior, and immunity · 2022Article
- Cancer and cancer survival modulates brain and behavior in a time-of-day-dependent manner in mice.Scientific reports · 2019Article
- funcExplorer: a tool for fast data-driven functional characterisation of high-throughput expression data.BMC genomics · 2018Article
- Circadian Plasticity in the Brain of Insects and Rodents.Frontiers in neural circuits · 2018Review
- The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids.Endocrine reviews · 2017Review
- Gene Expression Profiling of Evening Fatigue in Women Undergoing Chemotherapy for Breast Cancer.Biological research for nursing · 2016Article
- Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders.Molecular psychiatry · 2015Review
- Genetics and epigenetics of circadian rhythms and their potential roles in neuropsychiatric disorders.Neuroscience bulletin · 2015Review
- Article
- Diurnal oscillation of amygdala clock gene expression and loss of synchrony in a mouse model of depression.The international journal of neuropsychopharmacology · 2014Article
- RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder.Molecular psychiatry · 2014Article
- Disruption of daily rhythms in gene expression: the importance of being synchronised.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
- Circadian rhythms and mood: opportunities for multi-level analyses in genomics and neuroscience: circadian rhythm dysregulation in mood disorders provides clues to the brain's organizing principles, and a touchstone for genomics and neuroscience.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Major depressive disorder: a loss of circadian synchrony?BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure.Human molecular genetics · 2013Article
- Circadian patterns of gene expression in the human brain and disruption in major depressive disorder.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Sex difference in daily rhythms of clock gene expression in the aged human cerebral cortex.Journal of biological rhythms · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe prefrontal cortex is important in regulating sleep and mood. Diurnally regulated genes in the prefrontal cortex may be controlled by the circadian system, by sleep:wake states, or by cellular metabolism or environmental responses. Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances.
resultsWe examined gene expression in the mouse prefrontal cortex at four time points during a 24 hour (12 hour light:12 hour dark) cycle using microarrays, and identified 3,890 transcripts corresponding to 2,927 genes with diurnally regulated expression patterns. We show that 16% of the genes identified in our study are orthologs of identified clock, clock controlled or sleep/wakefulness induced genes in the mouse liver and suprachiasmatic nucleus, rat cortex and cerebellum, or Drosophila head. The diurnal expression patterns were confirmed for 16 out of 18 genes in an independent set of RNA samples. The diurnal genes fall into eight temporal categories with distinct functional attributes, as assessed by Gene Ontology classification and analysis of enriched transcription factor binding sites.
conclusionOur analysis demonstrates that approximately 10% of transcripts have diurnally regulated expression patterns in the mouse prefrontal cortex. Functional annotation of these genes will be important for the selection of candidate genes for behavioral mutants in the mouse and for genetic studies of disorders associated with anomalies in the sleep:wake cycle and circadian rhythm.
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