Evidence map›Paper›PMID 18028543›Full record

ArticleGenome biology2007

Analysis of molecular inversion probe performance for allele copy number determination.

Yuker Wang, Martin Moorhead, George Karlin-Neumann, Nicholas J Wang, James Ireland, Steven Lin, Chunnuan Chen, Laura M Heiser, Koei Chin, Laura Esserman and 3 more

Abstract read
In one paragraph

Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Genetic evaluation of juvenile xanthogranuloma: genomic abnormalities are uncommon in solitary lesions, advanced cases may show more complexity.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017
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  9. Copy number analysis of ductal carcinoma in situ with and without recurrence.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015
    Article
  10. Article
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  13. Bayesian hierarchical structured variable selection methods with application to MIP studies in breast cancer.Journal of the Royal Statistical Society. Series C, Applied statistics · 2014
    Article
  14. Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuker WangAffymetrix Inc, Shoreline Blvd, South San Francisco, CA 94080, USA. Yuker_Wang@affymetrix.com
Martin Moorhead
George Karlin-Neumann
Nicholas J Wang
James Ireland
Steven Lin
Chunnuan Chen
Laura M Heiser
Koei Chin
Laura Esserman
Joe W Gray
Paul T Spellman
Malek Faham

Funding

Systems-Based Predictions of Responses to Cancer TherapyU54CA112970 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI GRAY, JOE W. · 2004 to 2014
$27.1M
NCI NIH HHS U54 CA112970NCI NIH HHS U54CA112970
6 · The paper itself

Abstract

We have developed a new protocol for using molecular inversion probes to accurately and specifically measure allele copy number. The new protocol provides for significant improvements, including the reduction of input DNA (from 2 mug) by more than 25-fold (to 75 ng total genomic DNA), higher overall precision resulting in one order of magnitude lower false positive rate, and greater dynamic range with accurate absolute copy number up to 60 copies.

Indexed as

AllelesChromosome InversionMolecular ProbesCell Line, TumorChromosome AberrationsFalse Positive ReactionsHumansLoss of HeterozygosityPolymerase Chain ReactionROC CurveMolecular Probes

Identifiers

PMID18028543
PMCPMC2258201

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.