ArticleBMC developmental biology2007
Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity.
Article in BMC developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Folic acid supplementation on congenital heart disease and its dual character.Current research in pharmacology and drug discovery · 2025Review
- Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Induced Carcinogenesis and Tumorigenesis by Omega-3 Fatty Acids in Mice In Vivo.International journal of molecular sciences · 2024Article
- Immunodeficiency associated with a novel functionally defective variant of SLC19A1 benefits from folinic acid treatment.Genes and immunity · 2023Article
- Association of polymorphisms of FOLR1 gene and FOLR2 gene and maternal folic acid supplementation with risk of ventricular septal defect: a case-control study.European journal of clinical nutrition · 2022Article
- Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Mediated Pulmonary DNA Adducts and Cytochrome P450 (CYP)1B1 by Dietary Antioxidants, Omega-3 Fatty Acids, in Mice.Antioxidants (Basel, Switzerland) · 2022Article
- Site-specific glycoproteomic analysis revealing increased core-fucosylation on FOLR1 enhances folate uptake capacity of HCC cells to promote EMT.Theranostics · 2021Article
- Mutations in folate transporter genes and risk for human myelomeningocele.American journal of medical genetics. Part A · 2017Article
- Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy.Disease models & mechanisms · 2014Article
- Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6.The Journal of biological chemistry · 2013Article
- Molecular mechanisms underlying the potentially adverse effects of folate.Clinical chemistry and laboratory medicine · 2013Review
- Nuclear localization of folate receptor alpha: a new role as a transcription factor.Scientific reports · 2012Article
- Article
- Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse.PloS one · 2011Article
- Article
- Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele.Birth defects research. Part A, Clinical and molecular teratology · 2010Article
- Folate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient mice.The Journal of biological chemistry · 2010Article
- Representing ontogeny through ontology: a developmental biologist's guide to the gene ontology.Molecular reproduction and development · 2010Review
- Gene expression profiling of mouse embryos with microarrays.Methods in enzymology · 2010Article
- Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development.The Journal of clinical investigation · 2009Article
- Episcopic 3D Imaging Methods: Tools for Researching Gene Function.Current genomics · 2008Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHeart anomalies are the most frequently observed among all human congenital defects. As with the situation for neural tube defects (NTDs), it has been demonstrated that women who use multivitamins containing folic acid peri-conceptionally have a reduced risk for delivering offspring with conotruncal heart defects 123. Cellular folate transport is mediated by a receptor or binding protein and by an anionic transporter protein system. Defective function of the Folr1 (also known as Folbp1; homologue of human FRalpha) gene in mice results in inadequate transport, accumulation, or metabolism of folate during cardiovascular morphogenesis.
resultsWe have observed cardiovascular abnormalities including outflow tract and aortic arch arterial defects in genetically compromised Folr1 knockout mice. In order to investigate the molecular mechanisms underlying the failure to complete development of outflow tract and aortic arch arteries in the Folr1 knockout mouse model, we examined tissue-specific gene expression difference between Folr1 nullizygous embryos and morphologically normal heterozygous embryos during early cardiac development (14-somite stage), heart tube looping (28-somite stage), and outflow track septation (38-somite stage). Microarray analysis was performed as a primary screening, followed by investigation using quantitative real-time PCR assays. Gene ontology analysis highlighted the following ontology groups: cell migration, cell motility and localization of cells, structural constituent of cytoskeleton, cell-cell adhesion, oxidoreductase, protein folding and mRNA processing. This study provided preliminary data and suggested potential candidate genes for further description and investigation.
conclusionThe results suggested that Folr1 gene ablation and abnormal folate homeostasis altered gene expression in developing heart and conotruncal tissues. These changes affected normal cytoskeleton structures, cell migration and motility as well as cellular redox status, which may contribute to cardiovascular abnormalities in mouse embryos lacking Folr1 gene activity.
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