Evidence map›Paper›PMID 18027049›Full record

ArticleSurgical endoscopy2008

Gastric bypass pouch and stoma reduction using a transoral endoscopic anchor placement system: a feasibility study.

Daniel M Herron, Desmond H Birkett, Chris C Thompson, Marc Bessler, Lee L Swanström

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02302898 (Characteristics Associated With Weight Regain After Roux-en-Y Gastric Bypass), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02302898 completednot on this mapstarted 2015, after this paper: background citation

Characteristics Associated With Weight Regain After Roux-en-Y Gastric Bypass

TypeobservationalSponsorWashington University School of MedicineRan2015 to 2016Enrolled2ConditionsObesityArmsEating Behavior Evaluation, Measurement of Functional gastric volume, Measurement of gastric pouch and GJ size
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 59 citations in OpenAlex.

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  12. Obesity and bariatrics for the endoscopist: new techniques.Therapeutic advances in gastroenterology · 2011
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  13. Article
  14. Gastrojejunal stoma diameter predicts weight regain after Roux-en-Y gastric bypass.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2011
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  18. Endoscopic therapy for GERD: does it have a future?Current gastroenterology reports · 2008
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Daniel M HerronDivision of Laparoscopic Surgery, Department of Surgery, Mount Sinai School of Medicine, 1 Gustave L. Levy Place #1259, New York, NY 10029, USA. daniel.herron@mountsinai.org
Desmond H Birkett
Chris C Thompson
Marc Bessler
Lee L Swanström
Brigham and Women's Hospital · USIcahn School of Medicine at Mount Sinai · USLahey Hospital and Medical Center · USLegacy Health · USPresbyterian Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWeight regain after Roux-en-Y gastric bypass may be caused by pouch enlargement or dilatation of the gastrojejunostomy (stoma). In order to avoid the substantial morbidity of revisional bariatric surgery, investigators have recently demonstrated the feasibility of reducing stoma diameter using transoral endoscopic suturing techniques. Our aim was to demonstrate the feasibility of performing both pouch and stomal reduction using transoral endoscopically placed tissue anchors in an ex vivo and acute animate model.

methodsPart I: We created an ex vivo model of a dilated gastric pouch and stoma using four explanted porcine stomachs. The stomach was divided to create an upper pouch of approx. 100 ml volume, which was reconnected to the lower portion of the stomach (gastric remnant) via an anastomosis of 18 to 20 mm diameter. Endoscopically placed anchors were then used to create plications of the stoma and reduce its diameter. In two stomachs, anchor plications were also used to decrease pouch volume. Pouch volumes and stoma diameters were measured pre- and post-procedure. Part II: A similar experimental model was created in vivo using three pigs. Anchors were placed in the stoma and pouch. The animals were immediately sacrificed and similar measurements were obtained.

resultsIn the ex vivo model, stoma diameter was successfully reduced in all four stomachs by a mean of 8 mm (41%). This represented a mean decrease in cross-sectional area of 65%. Pouch volume was reduced by a mean of 28 ml (30%) in two stomachs. Stomal plications were successfully placed in two of the live animals, with a mean stoma diameter reduction of 11.5 mm (53%). Feasibility of pouch reduction using plicating anchors was confirmed.

conclusionsThis is the first study to demonstrate the feasibility of using endoscopically placed tissue anchors to reduce both stoma diameter and pouch volume. This technique may ultimately be clinically useful in treating weight regain after gastric bypass surgery.

Indexed as

Endoscopy, GastrointestinalGastric BypassSurgical StomasAnastomosis, Roux-en-YAnimalsFeasibility StudiesSurgical InstrumentsSwine

Identifiers

PMID18027049
OpenAlexW2082429697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.