ArticleMammalian genome : official journal of the International Mammalian Genome Society2007
Mapping quantitative trait loci for canine hip dysplasia in German Shepherd dogs.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Genome-wide association studies for canine hip dysplasia in single and multiple populations - implications and potential novel risk loci.BMC genomics · 2021Pooled it
- Genetic Variability in Polish Lowland Sheepdogs Assessed by Pedigree and Genomic Data.Animals : an open access journal from MDPI · 2020Article
- The association of genetic polymorphisms of bone formation genes with canine hip dysplasia.Iranian journal of veterinary research · 2020Article
- Novel protective and risk loci in hip dysplasia in German Shepherds.PLoS genetics · 2019Article
- A recurrent mutation in bone morphogenetic proteins-2-inducible kinase gene is associated with developmental dysplasia of the hip.Experimental and therapeutic medicine · 2017Article
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- A genetic predictive model for canine hip dysplasia: integration of Genome Wide Association Study (GWAS) and candidate gene approaches.PloS one · 2015Article
- Emerging insights into the genetic basis of canine hip dysplasia.Veterinary medicine (Auckland, N.Z.) · 2015Review
- Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers.BMC genomics · 2014Article
- Multiple loci associated with canine hip dysplasia (CHD) in German shepherd dogs.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
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- Identification and validation of quantitative trait loci (QTL) for canine hip dysplasia (CHD) in German Shepherd Dogs.PloS one · 2014Article
- Identification of quantitative trait loci (QTL) for canine hip dysplasia and canine elbow dysplasia in Bernese mountain dogs.PloS one · 2012Article
- Heritability and phenotypic variation of canine hip dysplasia radiographic traits in a cohort of Australian German shepherd dogs.PloS one · 2012Article
- Canine hip dysplasia is predictable by genotyping.Osteoarthritis and cartilage · 2011Article
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- The Otto Aufranc Award: Identification of a 4 Mb region on chromosome 17q21 linked to developmental dysplasia of the hip in one 18-member, multigeneration family.Clinical orthopaedics and related research · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine hip dysplasia (CHD) is a common hereditary developmental disease of the coxofemoral joints. CHD is characterized by subluxation of the femoral head and deformation of the acetabulum leading to a painful osteoarthrosis. Analyses of mode of inheritance have shown the involvement of a major gene in expression of CHD in German Shepherd dogs. Thus, a whole genome scan for quantitative trait loci (QTL) was performed in German Shepherd dogs. For this purpose 11 paternal half-sib families, including a total of 459 purebred German Shepherd dogs with sires, dams, and offspring, were genotyped for 261 microsatellites. These markers were equidistantly distributed over all 38 autosomes and the X chromosome with an average marker distance of 11.7 cM. The mean observed heterozygosity of the marker set was 50%. The CHD status for the dogs was scored according to the official rules of the Fédération Cynologique Internationale. At the genome-wide level of significance at p < 0.05, QTL for CHD were located on nine different canine chromosomes: 1, 3, 4, 8, 9, 16, 19, 26, and 33. The minimal QTL regions containing the CHD genes spanned on average 5 Mb with a range between 1 and 8.2 Mb. Chromosome-wide level of significance at p < 0.05 was found for QTL on 19 chromosomes. Further analyses can now be performed to refine these map positions of QTL already identified in German Shepherd dogs.
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