ArticleInvertebrate neuroscience : IN2007
Genes encoding putative biogenic amine receptors in the parasitic nematode Brugia malayi.
Article in Invertebrate neuroscience : IN, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Computational Analysis of Missense Variants of G Protein-Coupled Receptors Involved in the Neuroendocrine Regulation of Reproduction.Neuroendocrinology · 2016Article
- A characterization of the Manduca sexta serotonin receptors in the context of olfactory neuromodulation.PloS one · 2013Article
- Biogenic amines and the control of neuromuscular signaling in schistosomes.Invertebrate neuroscience : IN · 2012Review
- Molecular expression and characterization of a novel protein phosphatase 2A gene from Clonorchis sinensis.Parasitology research · 2012Article
- Monoaminergic signaling as a target for anthelmintic drug discovery: receptor conservation among the free-living and parasitic nematodes.Molecular and biochemical parasitology · 2012Review
- Targeting protein-protein interactions for parasite control.PloS one · 2011Article
- The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The genome of Brugia malayi - all worms are not created equal.Parasitology international · 2009Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Filarial nematodes, such as Brugia malayi, cause major health problems worldwide. The lack of a vaccine against B. malayi, combined with ineffective chemotherapy against the adult has prompted the examination of biogenic amine receptors (BARs) as possible targets for drug discovery. We employed bioinformatics to identify genes encoding putative B. malayi BARs. Surprisingly, the B. malayi genome contains half of the genes predicted to encode BARs in the genomes of free-living nematodes such as Caenorhabditis elegans or C. briggsae; however, all of the predicted B. malayi receptors have clear orthologues in C. elegans. The B. malayi genes encode each of the major BAR subclasses, including three serotonin, two dopamine and two tyramine/octopamine receptors and the structure of orthologous BAR genes is conserved. We find that potential G-protein coupling and ligand-specificity of individual BARs may be predicted by phylogenetic comparisons. Our results provide a framework for how G-protein coupled receptors may be targeted for drug development in medically important parasitic nematodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.