Evidence map›Paper›PMID 18026997›Full record

ArticlePediatric nephrology (Berlin, Germany)2008

Dimercaptosuccinic acid (DMSA) renal scan in the evaluation of hypertension in children.

Maheen Ahmed, Daniel Eggleston, Gaurav Kapur, Amrish Jain, Rudolph P Valentini, Tej K Mattoo

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

  1. Renal trauma in a pediatric Level 1 trauma center: morbidity, mortality, and the role of renal scintigraphy.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  2. Review
  3. Primary vesicoureteral reflux.Nature reviews. Disease primers · 2024
    Review
  4. Article
  5. Diagnostic evaluation of the hypertensive child.Pediatric nephrology (Berlin, Germany) · 2024
    Article
  6. Article
  7. Article
  8. Dimercaptosuccinic acid scintigraphy vs. ultrasound for renal parenchymal defects in children.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2017
    Article
  9. Article
  10. Evaluation of hypertension in children.Current hypertension reports · 2013
    Review
  11. Prediction of primary vs secondary hypertension in children.Journal of clinical hypertension (Greenwich, Conn.) · 2012
    Article
  12. Managing urinary tract infections.Pediatric nephrology (Berlin, Germany) · 2011
    Review
  13. Vesicoureteral reflux and reflux nephropathy.Advances in chronic kidney disease · 2011
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maheen AhmedPediatric Nephrology and Hypertension, Children's Hospital of Michigan, Detroit, MI, USA.
Daniel Eggleston
Gaurav Kapur
Amrish Jain
Rudolph P Valentini
Tej K Mattoo
Children's Hospital of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal scarring is known to be associated with hypertension. The primary objective of this study was to investigate the prevalence of renal scarring in children referred to our clinic with hypertension. The secondary objective was to compare renal ultrasound (US) examination with dimercaptosuccinic acid (DMSA) renal scan in diagnosing renal scars in these patients. The study included 159 patients who underwent DMSA renal scan as well as renal US for the evaluation of hypertension of unknown etiology. Thirty-three (21%) patients were found to have renal scars; their demographic details, including mean age and gender distribution, were not significantly different from those without renal scars. In comparison with the DMSA renal scan, sensitivity and specificity of renal US in diagnosing renal scars were 36% and 94%, respectively. In our study, in which the prevalence of scarring was 21%, this gave positive predictive and negative predictive values of 63% and 85%, respectively. In conclusion, our study indicates that renal scarring is present in 21% of otherwise healthy children who are evaluated for newly diagnosed hypertension, and renal US is not a sensitive imaging modality to rule out renal scarring.

Indexed as

RadiopharmaceuticalsTechnetium Tc 99m Dimercaptosuccinic AcidAdolescentChildChild, PreschoolCicatrixFemaleHumansHypertensionInfantKidney DiseasesMaleRadionuclide ImagingRetrospective StudiesUltrasonographyRadiopharmaceuticalsTechnetium Tc 99m Dimercaptosuccinic Acid

Identifiers

PMID18026997
OpenAlexW2040809146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.