ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2008
The old and the new: supratentorial MR findings in Chiari II malformation.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 111 citations in OpenAlex.
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- Prevalence of epilepsy and structural brain anomalies in spina bifida aperta.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Cognitive, neuroimaging, and genetic insights on the interthalamic adhesion from a large cohort study of 591 subjects.Scientific reports · 2025Article
- Characterizing the In Utero Phenome of the Chiari II Malformation-A Network Medicine Approach, Using Fetal MRI.Prenatal diagnosis · 2025Article
- Multiparametric prenatal imaging characterization of fetal brain edema in Chiari II malformation might help to select candidates for fetal surgery.European radiology · 2024Article
- Memory in Spina Bifida, from Childhood to Adulthood: A Systematic Review.Journal of clinical medicine · 2024Review
- Exploring the impact of the interthalamic adhesion on human cognition: insights from healthy subjects and thalamic stroke patients.Journal of neurology · 2024Article
- Assessment of longitudinal brain development using super-resolution magnetic resonance imaging following fetal surgery for open spina bifida.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2023Article
- Adults with spina bifida: ambulatory performance and cognitive capacity in relation to muscle function.Spinal cord · 2022Article
- The Role of Fetal Brain Magnetic Resonance Imaging in Current Fetal Medicine.Journal of the Belgian Society of Radiology · 2022Article
- Cortical spectral matching and shape and volume analysis of the fetal brain pre- and post-fetal surgery for spina bifida: a retrospective study.Neuroradiology · 2021Article
- Incidence and patterns of abnormal corpus callosum in fetuses with isolated spina bifida aperta.Prenatal diagnosis · 2021Observational
- Myelomeningocele-Chiari II malformation-Neurological predictability based on fetal and postnatal magnetic resonance imaging.Prenatal diagnosis · 2021Article
- Definitions and classification of malformations of cortical development: practical guidelines.Brain : a journal of neurology · 2020Review
- Brain abnormalities in myelomeningocele patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Interhypothalamic adhesions in endoscopic third ventriculostomy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Incidentally detected total agenesis of the falx cerebri: Potential significance of this rare finding.European journal of radiology open · 2019Article
- Hypothalamic Adhesions: Asymptomatic, Incidental, or Not?AJNR. American journal of neuroradiology · 2016Article
- Evaluation of Subependymal Gray Matter Heterotopias on Fetal MRI.AJNR. American journal of neuroradiology · 2016Article
- MR assessment of pediatric hydrocephalus: a road map.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
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5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe objective of this study was to use magnetic resonance imaging to develop an improved morphological understanding of the abnormalities of the forebrain in Chiari II malformation. MATERIALS AND
methodsSeventy-four patients with Chiari II malformations investigated between 1999 and 2007 were enrolled. Imaging was retrospectively reviewed by two pediatric neuroradiologists, with special attention given to diencephalon, midline commissures, hemispheric white matter, and cortex.
resultsAn abnormal gray matter structure that we called hypothalamic adhesion across the anterior-inferior portion of the third ventricle was noted in 48.6%. The anterior commissure was in a low position in the lamina terminalis in 38%. Gross abnormalities of the corpus callosum/hippocampal commissure were found in 57%; they were, however, different from the abnormalities seen in classical commissural agenesis. An abnormal bundle of white matter forming a callosal ridge was noted on the dorsal callosal surface in 60%; it is believed to represent the aberrant cingular bundle recently identified using diffusion tensor imaging. Hemispheric white matter could be considered as normal in 48%, deficient posteriorly in 55%, and globally in 10%. Cortical posterior medial stenogyria was observed in 72%. Gray matter heterotopias were found in 19%. The posterior limbic cortex was thin and dysplastic in 46%. Hippocampi were commonly abnormal (85%), with atypical sulcation of the adjacent temporo-mesial cortex (93%).
conclusionMajor structural abnormalities were common in Chiari II malformation and were probably not related to hydrocephalus. Important anatomical structures involved in neurocognitive function should be considered as factors in the prognostic assessment of Chiari II patients.
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