Evidence map›Paper›PMID 18026941›Full record

ArticleEuropean journal of clinical pharmacology2008

Prevalence and patterns of methylphenidate use in French children and adolescents.

Anne-Laure Knellwolf, Jean Deligne, Flavia Chiarotti, Guy-Robert Auleley, Serena Palmieri, Claudine Blum Boisgard, Pietro Panei, Elisabeth Autret-Leca

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Article in European journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. Pediatric psychopharmacology: Too much and too little.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2013
    Article
  11. Article
  12. Article
  13. Review
  14. Childhood attention problems and socioeconomic status in adulthood: 18-year follow-up.The British journal of psychiatry : the journal of mental science · 2012
    Article
  15. Article
  16. Article
  17. Article
  18. A three-country comparison of psychotropic medication prevalence in youth.Child and adolescent psychiatry and mental health · 2008
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anne-Laure KnellwolfClinical Research Unit, Department of Drug Research and Evaluation, Italian National Institute of Health, viale Regina Elena 299, 00161 Rome, Italy. anne.knellwolf@iss.it
Jean Deligne
Flavia Chiarotti
Guy-Robert Auleley
Serena Palmieri
Claudine Blum Boisgard
Pietro Panei
Elisabeth Autret-Leca

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the study was to describe the prevalence and utilization patterns of methylphenidate (MPH) in children and adolescents in France.

methodsThis was a population-based retrospective study in which the cohort consisted of patients for whom data were extracted from the dispensation drug claims database of the national health insurance (NHI) fund for self-employed workers. Annual prevalence of MPH use was evaluated on patients aged 6-18 years who were reimbursed for at least one MPH prescription a year. Between January 2004 and June 2005, features of MPH medication and user profile were described for the "new starters" having a screening period of 1 year without receiving a MPH prescription and a follow-up >or=12 months. Time to interruption of MPH regular use was analysed by Kaplan-Meier survival analysis. Mean duration of exposure to MPH treatment was computed with the 95% confidence interval (CI).

resultsAnnual prevalence of MPH per 1000 persons was 1.1 in 2003, 1.5 in 2004 and 1.8 in 2005 (relative increase of 63.5%). New starters (n = 447) received their first MPH prescription through the hospital (65.1%) or through private practitioners (34.9%). The user profiles were: short (16.6%), occasional (33.8%) and regular (49.6%). Among the new starters, the median time to interruption of MPH regular use was 10.2 months (95% CI: 7.9-12.4). The mean duration of exposure to MPH treatment was: occasional (4.9 months, 95% CI: 4.3-5.5) and regular (25.7 months, 95% CI: 24.6-26.8).

conclusionAlthough there is a low prevalence of MPH use in France, this survey revealed a wide profile of users and heterogeneous use patterns.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildCohort StudiesDatabases, FactualDrug Administration ScheduleFemaleFollow-Up StudiesFranceHumansInsurance, Pharmaceutical ServicesKaplan-Meier EstimateMaleMethylphenidatePractice Patterns, Physicians'Central Nervous System StimulantsMethylphenidate

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.