ReviewJournal of mammary gland biology and neoplasia2007
Translational regulation of milk protein synthesis at secretory activation.
Review in Journal of mammary gland biology and neoplasia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- Network analysis of the proteome and peptidome sheds light on human milk as a biological system.Scientific reports · 2024Article
- Branched-chain amino acids regulate intracellular protein turnover in porcine mammary epithelial cells.Amino acids · 2022Article
- Identification of circRNA-Associated-ceRNA Networks Involved in Milk Fat Metabolism under Heat Stress.International journal of molecular sciences · 2020Article
- Effect of stearic or oleic acid on milk performance and energy partitioning when fed in diets with low and high rumen-active unsaturated fatty acids in early lactation.Journal of animal science · 2019Article
- RNA-Seq reveals novel genes and pathways involved in bovine mammary involution during the dry period and under environmental heat stress.Scientific reports · 2018Article
- Moderate High Temperature Condition Induces the Lactation Capacity of Mammary Epithelial Cells Through Control of STAT3 and STAT5 Signaling.Journal of mammary gland biology and neoplasia · 2018Article
- SESN2 negatively regulates cell proliferation and casein synthesis by inhibition the amino acid-mediated mTORC1 pathway in cow mammary epithelial cells.Scientific reports · 2018Article
- Integration of GWAS, pathway and network analyses reveals novel mechanistic insights into the synthesis of milk proteins in dairy cows.Scientific reports · 2018Article
- Genome-association analysis of Korean Holstein milk traits using genomic estimated breeding value.Asian-Australasian journal of animal sciences · 2017Article
- ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Unmasking Upstream Gene Expression Regulators with miRNA-corrected mRNA Data.Bioinformatics and biology insights · 2015Article
- CPEB1 promotes differentiation and suppresses EMT in mammary epithelial cells.Journal of cell science · 2014Article
- Leucyl-tRNA synthetase regulates lactation and cell proliferation via mTOR signaling in dairy cow mammary epithelial cells.International journal of molecular sciences · 2014Article
- Expression profiles of microRNAs from lactating and non-lactating bovine mammary glands and identification of miRNA related to lactation.BMC genomics · 2012Article
- Transcriptome analysis of epithelial and stromal contributions to mammogenesis in three week prepartum cows.PloS one · 2011Article
- Gene networks driving bovine mammary protein synthesis during the lactation cycle.Bioinformatics and biology insights · 2011Article
- Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction.The Journal of biological chemistry · 2010Article
- c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland.BMC biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Studies conducted since the 1970s have revealed that the production of milk proteins in the mammary gland under the influence of lactogenic hormones (insulin, prolactin, and glucocorticoids) is regulated at multiple levels. Whereas earlier studies concentrated on transcriptional regulation and stabilization of milk protein mRNAs, more recent studies have revealed that translation of milk protein mRNAs is also dependent on lactogenic hormones. A general stimulation of translation in mammary epithelial cells is caused by amino acids (as signaling molecules) or by phosphorylation of the translational regulator 4E-BP1 in a synergistic response to signals from insulin and prolactin. However, a selective enhancement of milk protein mRNA translation is caused by cytoplasmic polyadenylation of mRNA, again in a synergistic response to these two hormones. Preliminary evidence indicates that the latter effect depends on the existence of a cytoplasmic polyadenylation element (CPE) in milk protein mRNAs and phosphorylation of its binding protein, CPEB. Experiments in whole animals, organ explants, and cell culture have shown that the poly(A) length of milk protein mRNAs changes as a function of the lactation cycle. Interestingly, cytoplasmic polyadenylation is likely to be responsible for the selective hormone-dependent enhancement of both translation and stability of milk protein mRNAs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.