ArticleDevelopment genes and evolution2007
Lens gene expression analysis reveals downregulation of the anti-apoptotic chaperone alphaA-crystallin during cavefish eye degeneration.
Article in Development genes and evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Novel mechanisms of chemosensory adaptation to the cave environment.bioRxiv : the preprint server for biology · 2026Article
- CRISPR screening reveals genetic regulators associated with the evolution of eye degeneration.bioRxiv : the preprint server for biology · 2025Article
- Metabolic shift toward ketosis in asocial cavefish increases social-like affinity.BMC biology · 2023Article
- Article
- Comparative Transcriptome Profiling of the LoachesFrontiers in genetics · 2019Article
- Embryonic origin and genetic basis of cave associated phenotypes in the isopod crustacean Asellus aquaticus.Scientific reports · 2018Article
- Maternal genetic effects in Astyanax cavefish development.Developmental biology · 2018Article
- Complexities of gene expression patterns in natural populations of an extremophile fish (Poecilia mexicana, Poeciliidae).Molecular ecology · 2017Article
- Cavefish and the basis for eye loss.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Lens apoptosis in the Astyanax blind cavefish is not triggered by its small size or defects in morphogenesis.PloS one · 2017Article
- Article
- The cavefish genome reveals candidate genes for eye loss.Nature communications · 2014Article
- The role of a lens survival pathway including sox2 and αA-crystallin in the evolution of cavefish eye degeneration.EvoDevo · 2014Article
- Loss of the small heat shock protein αA-crystallin does not lead to detectable defects in early zebrafish lens development.Experimental eye research · 2013Article
- Article
- Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish.Molecular biology and evolution · 2013Article
- Comparative proteomics analysis of degenerative eye lenses of nocturnal rice eel and catfish as compared to diurnal zebrafish.Molecular vision · 2013Article
- Changes in zebrafish (Danio rerio) lens crystallin content during development.Molecular vision · 2013Article
- Lens fibre cell differentiation and organelle loss: many paths lead to clarity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation.Epigenetics & chromatin · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have conducted a survey of the expression patterns of five genes encoding three different classes of major lens proteins during eye degeneration in the blind cavefish Astyanax mexicanus. This species consists of two forms, an eyed surface-dwelling form (surface fish) and a blind cave-dwelling (cavefish) form. Cavefish form an optic primordium with a lens vesicle and optic cup. In contrast to surface fish, however, the cavefish lens does not differentiate fiber cells and undergoes massive apoptosis. The genes encoding the lens intrinsic membrane proteins MIP and MP19 and the divergent betaB1- and gammaM2-crystallins are expressed during cavefish lens development, although their levels are reduced because of a smaller lens, and the spatial distribution of their transcripts is modified because of the lack of differentiated fiber cells. In contrast, the alphaA-crystallin gene, which encodes a heat shock protein-related chaperone with antiapoptotic activity, is substantially downregulated in the developing cavefish lens. The results suggest that suppression of alphaA-crystallin antiapoptotic activity may be involved in cavefish eye degeneration.
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