Evidence map›Paper›PMID 18026720›Full record

ArticlePsychopharmacology2008

Imbalance of a serotonergic system in frontotemporal dementia: implication for pharmacotherapy.

D M Bowen, A W Procter, D M A Mann, J S Snowden, M M Esiri, D Neary, P T Francis

Abstract read
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In one paragraph

Article in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Depression and apathy in frontotemporal dementia: a short assessment of facts and outlook.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  5. Article
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  9. The Role of Oxytocin in Social Circuits and Social Behavior in Dementia.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
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  11. Article
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  13. Article
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  16. Article
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  18. Article
  19. Review
  20. Kinetics of serotonin oxidation by heme-Aβ relevant to Alzheimer's disease.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

D M BowenDepartment of Neuropathology, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
A W Procter
D M A Mann
J S Snowden
M M Esiri
D Neary
P T Francis
University of Salford · GBJohn Radcliffe Hospital · GBKing's College London · GBManchester Royal Infirmary · GBUniversity of Manchester · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleInformation is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD).

objectivesTo evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as these may help in developing treatment. MATERIALS AND

methodsPost-mortem grey matter from Brodmann Area 21, 9 and 7 of 51 brains was assayed for ten neurochemical parameters indexing neurotransmission. Repeated measures analyses of variance were carried out for each parameter comparing groups (FTD vs AD vs control) at each anatomical site.

resultsIn FTD only the indices of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid, serotonin (5-HT)(1A) and 5-HT(2A) receptors were significantly reduced from control values. Of the ten parameters only 5-HT(1A) receptors showed significant group x site interaction. This reflected disproportionate reduction in frontal and temporal compared to parietal cortex. In FTD three other receptors (muscarinic, M(1), N-methyl-D: -aspartate, NMDA, and kainate), choline acetyltransferase (ChAT) activity, 5-HT and 5-hydroxyindoleacetic acid content and 5-HT reuptake site values were not significantly reduced from control values. Only 5-HT, 5-HT reuptake site and ChAT values were significantly higher in FTD than AD. NMDA receptor and ChAT values were significantly reduced from control only in AD.

conclusionsNeurochemical results in FTD indicate degeneration and loss of pyramidal neurones in frontotemporal neocortex, yet 5-HT afferents and 5-HT concentration, which are inhibitory on pyramidal neurones, were relatively preserved. This could lead to an excess of extraneural 5-HT causing underactivity of surviving pyramidal neurones. Pharmacotherapy with a 5-HT(1A) receptor antagonist may be indicated.

Indexed as

Agedalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAlzheimer DiseaseCholine O-AcetyltransferaseDementiaFemaleFrontal LobeHumansKainic Acid ReceptorsMaleMiddle AgedParietal LobePostmortem ChangesReceptor, Muscarinic M1Receptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2Aalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidCholine O-AcetyltransferaseKainic Acid ReceptorsReceptor, Muscarinic M1Receptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptors, GlutamateReceptors, N-Methyl-D-AspartateReceptors, Serotonin

Identifiers

PMID18026720
OpenAlexW2012002443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.