ArticleNaunyn-Schmiedeberg's archives of pharmacology2008
Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Calcineurin inhibitor effects on kidney electrolyte handling and blood pressure: tacrolimus versus voclosporin.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Magnesium biology.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Review
- Magnesium and Vascular Calcification in Chronic Kidney Disease: Current Insights.International journal of molecular sciences · 2024Review
- Article
- NaCl cotransporter activity and MgAmerican journal of physiology. Renal physiology · 2020Review
- Pathophysiology of Drug-Induced Hypomagnesaemia.Drug safety · 2020Review
- Sodium Citrate Increases Expression and Flux of MgNutrients · 2018Article
- Proton-pump inhibitors do not influence serum magnesium levels in renal transplant recipients.Journal of nephrology · 2014Article
- Hypomagnesemia: a clinical perspective.International journal of nephrology and renovascular disease · 2014Review
- Article
- TRPM channels: same ballpark, different players, and different rules in immunogenetics.Immunogenetics · 2011Review
- Regulation of magnesium reabsorption in DCT.Pflugers Archiv : European journal of physiology · 2009Review
- Molecular determinants of magnesium homeostasis: insights from human disease.Journal of the American Society of Nephrology : JASN · 2008Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient receptor potential melastatin 6 (TRPM6) is distributed along the apical membrane of the renal tubular cells and is involved in the reabsorption of magnesium. In this study, we show that TRPM6 expression is suppressed by cyclosporin A (CsA) via a down-regulation of c-Fos expression. TRPM6 was expressed in NRK-52E, but not in Madin-Darby canine kidney cells. In contrast, its homolog, TRPM7, was equally expressed in both cells. In NRK-52E cells, CsA dose-dependently decreased TRPM6 expression without affecting TRPM7 expression. Magnesium load measurements revealed the rise in the intracellular free magnesium concentration ([Mg2+]i) to be inhibited by CsA. The transfection of TRPM6 siRNA decreased TRPM6 expression without affecting TRPM7 expression and inhibited the elevation of [Mg2+]i. CsA did not affect the intracellular distribution of nuclear factor of activated T cells (NFATc). Furthermore, TRPM6 expression was not changed by a NFATc inhibitor. Next, we examined the effect of CsA on the transcription factors c-Fos and c-Jun. CsA decreased c-Fos expression without affecting c-Jun expression. The transfection of c-Fos siRNA suppressed TRPM6 expression without affecting TRPM7 expression. We suggest that CsA decreases TRPM6 expression mediated by inhibition of c-Fos transcription, resulting in a decrease of renal Mg2+ reabsorption.
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