ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2008
Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Pooled it
- Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis.BMC medical genetics · 2008Pooled it
- The Wnt/β-catenin signaling pathway has a healing ability for periapical periodontitis.Scientific reports · 2021Article
- LRP5 gene polymorphisms and radiographic joint damage in rheumatoid arthritis patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish.Scientific reports · 2018Article
- Polymorphism of the low-density lipoprotein receptor-related protein 5 gene and fracture risk.International journal of clinical and experimental medicine · 2014Article
- Association of LRP5 haplotypes with osteoporosis in Mexican women.Molecular biology reports · 2013Article
- Control of bone formation by the serpentine receptor Frizzled-9.The Journal of cell biology · 2011Article
- No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families.Acta pharmacologica Sinica · 2010Article
- LRP5 gene polymorphism and cortical bone.Aging clinical and experimental research · 2010Article
- Molecular genetic studies of gene identification for osteoporosis: the 2009 update.Endocrine reviews · 2010Review
- Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
- Article
- Genetics of osteoporosis: accelerating pace in gene identification and validation.Human genetics · 2010Review
- WNT Signaling in osteoarthritis and osteoporosis: what is the biological significance for the clinician?Current rheumatology reports · 2009Review
- Article
Corrections and comments
- Erratum issued
- Erratum issuedLorentzson, M [corrected to Lorentzon, M]
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledHerein we investigated the association between polymorphisms in the LRP5 gene and bone phenotypes and fractures in three large male cohorts based on the rationale that mutations in LRP5 cause severe bone phenotypes. Results showed an association of the Val667Met SNP with spine BMD in 3,800 young and elderly men.
introductionThe low-density lipoprotein receptor-related protein 5 (LRP5)-Wnt signalling system is of importance for regulating osteoblastic activity, which became clear after findings that inactivating mutations in LRP5 cause osteoporosis. The overall aim of this study was to investigate the association between polymorphisms in the LRP5 gene and bone mineral density (BMD) in three large cohorts of young and elderly men.
methodsThe cohorts used were MrOS Sweden (n = 3014, aged 69-81 years) and MrOs Hong Kong (n = 2000, aged > 65 years) and the Swedish GOOD study (n = 1068, aged 18-20 years). The polymorphisms Val667Met and Ala1330Val were genotyped using a TaqMan assay.
resultsWhen combining the data from the Swedish cohorts in a meta-analysis (n = 3,800), men carrying the 667Met-allele had 3% lower BMD at lumbar spine compared with non-carriers (p < 0.05). The Val667Met SNP was not polymorphic in the Hong Kong population and thus were not included. There were no associations between the Ala1330Val SNP and bone phenotypes in the study populations. No associations between the LRP5 polymorphisms and self-reported fractures were seen in MrOs Sweden.
conclusionsResults from these three large cohorts indicate that the Val667Met polymorphism but not the Ala1330Val contributes to the observed variability in BMD in the Swedish populations.
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