Evidence map›Paper›PMID 18026577›Full record

Trial reportCanadian journal of gastroenterology = Journal canadien de gastroenterologie2007

Effect of a fermented milk combining Lactobacillus acidophilus Cl1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea: a randomized, double-blind, placebo-controlled trial.

M Beausoleil, N Fortier, S Guénette, A L'ecuyer, M Savoie, M Franco, J Lachaine, K Weiss

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Guideline
  7. Probiotics for the prevention of pediatric antibiotic-associated diarrhea.The Cochrane database of systematic reviews · 2019
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  15. Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways.Proceedings of the National Academy of Sciences of the United States of America · 2011
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  20. Comparative effectiveness of different therapies forThe Lancet regional health. Europe · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

M BeausoleilDepartment of Pharmacy, University of Montreal, Montreal, Canada. mbeausoleil.hmr@ssss.gouv.qc.ca
N Fortier
S Guénette
A L'ecuyer
M Savoie
M Franco
J Lachaine
K Weiss

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntibiotic-associated diarrhea is an important problem in hospitalized patients. The use of probiotics is gaining interest in the scientific community as a potential measure to prevent this complication. The main objective of the present study was to assess the efficacy and safety of a fermented milk combining Lactobacillus acidophilus and Lactobacillus casei that is widely available in Canada, in the prevention of antibiotic-associated diarrhea.

methodsIn this double-blind, randomized study, hospitalized patients were randomly assigned to receive either a lactobacilli-fermented milk or a placebo on a daily basis.

resultsAmong 89 randomized patients, antibiotic-associated diarrhea occurred in seven of 44 patients (15.9%) in the lactobacilli group and in 16 of 45 patients (35.6%) in the placebo group (OR 0.34, 95% CI 0.125 to 0.944; P=0.05). The median hospitalization duration was eight days in the lactobacilli group, compared with 10 days in the placebo group (P=0.09). Overall, the lactobacilli-fermented milk was well tolerated.

conclusionThe daily administration of a lactobacilli-fermented milk was safe and effective in the prevention of antibiotic-associated diarrhea in hospitalized patients.

Indexed as

Lacticaseibacillus caseiLactobacillus acidophilusAgedAged, 80 and overAnimalsAnti-Bacterial AgentsDiarrheaDouble-Blind MethodFemaleFermentationHumansLength of StayMaleMiddle AgedMilkOdds RatioAnti-Bacterial Agents

Identifiers

PMID18026577
PMCPMC2658588

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.