ArticleProceedings of the National Academy of Sciences of the United States of America2007
Development and regeneration of hair cells share common functional features.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ.Cell reports · 2024Article
- Multiple Calcium Channel Types with Unique Expression Patterns Mediate Retinal Signaling at Bipolar Cell Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Cisplatin Neurotoxicity Targets Specific Subpopulations and KFrontiers in cellular neuroscience · 2022Article
- SK Current, Expressed During the Development and Regeneration of Chick Hair Cells, Contributes to the Patterning of Spontaneous Action Potentials.Frontiers in cellular neuroscience · 2021Article
- Activity-Dependent Calcium Signaling in Neurons of the Medial Superior Olive during Late Postnatal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The local translation ofAging · 2019Article
- Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.Scientific reports · 2019Article
- Spontaneous and Acetylcholine Evoked Calcium Transients in the Developing Mouse Utricle.Frontiers in cellular neuroscience · 2019Article
- Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- Different CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Spiral ganglion cells and macrophages initiate neuro-inflammation and scarring following cochlear implantation.Frontiers in cellular neuroscience · 2015Article
- Preliminary characterization of voltage-activated whole-cell currents in developing human vestibular hair cells and calyx afferent terminals.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Association of the Kv1 family of K+ channels and their functional blueprint in the properties of auditory neurons as revealed by genetic and functional analyses.Journal of neurophysiology · 2013Article
- Electrical tuning and transduction in short hair cells of the chicken auditory papilla.Journal of neurophysiology · 2013Article
- Return of function after hair cell regeneration.Hearing research · 2013Review
- Posthearing Ca(2+) currents and their roles in shaping the different modes of firing of spiral ganglion neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The structural phenotype of neural connections in the auditory brainstem is sculpted by spontaneous and stimulus-induced neural activities during development. However, functional and molecular mechanisms of spontaneous action potentials (SAPs) in the developing cochlea are unknown. Additionally, it is unclear how regenerating hair cells establish their neural ranking in the constellation of neurons in the brainstem. We have demonstrated that a transient Ca(2+) current produced by the Ca(v)3.1 channel is expressed early in development to initiate spontaneous Ca(2+) spikes. Ca(v)1.3 currents, typical of mature hair cells, appeared later in development. Moreover, there is a surprising disappearance of the Ca(v)3.1 current that coincides with the attenuation of the transient Ca(2+) current as the electrical properties of hair cells transition to the mature phenotype. Remarkably, this process is recapitulated during hair-cell regeneration, suggesting that the transient expression of Ca(v)3.1 and the ensuing SAPs are signatures of hair cell development and regeneration.
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