ArticleGenome research2008
Genomics, transcriptomics, and peptidomics of neuropeptides and protein hormones in the red flour beetle Tribolium castaneum.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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Who cites it
131 citing papers in PubMed, 361 citations in OpenAlex.
- Article
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- Transcriptome Analysis of the Brain and Gnathal Ganglion Reveals Feeding-Mediated Genes inBiomolecules · 2026Article
- Clock-related neuropeptides inFrontiers in genetics · 2026Article
- Exploration of neuropeptides to identify potential target for regulating feeding behavior and development in Eurygaster integriceps.PloS one · 2026Article
- Transcriptome-Wide Identification of Neuropeptides and Neuropeptide Receptors in the Twenty-Eight-Spotted LadybirdInsects · 2025Article
- The cryptonephridial/rectal complex: an evolutionary adaptation for water and ion conservation.Biological reviews of the Cambridge Philosophical Society · 2025Review
- FMRFamide-like peptides (FaLPs) - an overview of diverse physiological roles in insects and other arthropods.International journal of biological sciences · 2025Review
- Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses.BMC genomics · 2024Article
- Novel regulation pathway of eclosion hormones in Tribolium castaneum by distinct transcription factors through the initiation of 20-hydroxyecdysone.The Journal of biological chemistry · 2024Article
- A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles.Scientific reports · 2024Article
- Gene redundancy and gene compensation of insulin-like peptides in the oocyte development of bean beetle.PloS one · 2024Article
- Identification and expression profiling of neuropeptides and neuropeptide receptor genes in a natural enemy,Frontiers in physiology · 2024Article
- Bioinformatic Prohormone Discovery in Basal Metazoans: Insights from Trichoplax.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Differential expression of ITP and ITPL indicate multiple functions in the silkworm Bombyx mori.Cell and tissue research · 2023Article
- Pigment-dispersing factor is present in circadian clock neurons of pea aphids and may mediate photoperiodic signalling to insulin-producing cells.Open biology · 2023Article
- Article
- Insulin-like peptide 8 (Ilp8) regulates female fecundity in flies.Frontiers in cell and developmental biology · 2023Article
- Neuropeptidomes ofJournal of proteome research · 2022Article
- Periviscerokinin (CapParasites & vectors · 2022Article
71 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptides and protein hormones are ancient molecules that mediate cell-to-cell communication. The whole genome sequence from the red flour beetle Tribolium castaneum, along with those from other insect species, provides an opportunity to study the evolution of the genes encoding neuropeptide and protein hormones. We identified 41 of these genes in the Tribolium genome by using a combination of bioinformatic and peptidomic approaches. These genes encode >80 mature neuropeptides and protein hormones, 49 peptides of which were experimentally identified by peptidomics of the central nervous system and other neuroendocrine organs. Twenty-three genes have orthologs in Drosophila melanogaster: Sixteen genes in five different groups are likely the result of recent gene expansions during beetle evolution. These five groups contain peptides related to antidiuretic factor-b (ADF-b), CRF-like diuretic hormone (DH37 and DH47 of Tribolium), adipokinetic hormone (AKH), eclosion hormone, and insulin-like peptide. In addition, we found a gene encoding an arginine-vasopressin-like (AVPL) peptide and one for its receptor. Both genes occur only in Tribolium and not in other holometabolous insects with a sequenced genome. The presence of many additional osmoregulatory peptides in Tribolium agrees well with its ability to live in very dry surroundings. In contrast to these extra genes, there are at least nine neuropeptide genes missing in Tribolium, including the genes encoding the prepropeptides for corazonin, kinin, and allatostatin-A. The cognate receptor genes for these three peptides also appear to be absent in the Tribolium genome. Our analysis of Tribolium indicates that, during insect evolution, genes for neuropeptides and protein hormones are often duplicated or lost.
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