ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2008
Genomic interrogation of ancestral Mycobacterium tuberculosis from south India.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 53 citations in OpenAlex.
- A comparative analysis of molecular genotypes ofFrontiers in cellular and infection microbiology · 2022Article
- Molecular diversity of Mycobacterium tuberculosis complex in Sikkim, India and prediction of dominant spoligotypes using artificial intelligence.Scientific reports · 2021Article
- Spoligotype Diversity ofInternational journal of microbiology · 2020Article
- Genotypic diversity of Mycobacterium tuberculosis isolates from North-Central Indian population.Pathogens and global health · 2019Article
- Molecular genotyping to differentiate endogenous reactivation and exogenous reinfection of recurrent tuberculosis.Journal of clinical tuberculosis and other mycobacterial diseases · 2018Article
- Evidence for Host-Bacterial Co-evolution via Genome Sequence Analysis of 480 Thai Mycobacterium tuberculosis Lineage 1 Isolates.Scientific reports · 2018Article
- Mycobacterium tuberculosis Whole Genome Sequences From Southern India Suggest Novel Resistance Mechanisms and the Need for Region-Specific Diagnostics.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Genetic diversity of Mycobacterium tuberculosis isolates from central India.The Indian journal of medical research · 2016Article
- Mycobacterium tuberculosis causing tuberculous lymphadenitis in Maputo, Mozambique.BMC microbiology · 2015Article
- Genetic markers, genotyping methods & next generation sequencing in Mycobacterium tuberculosis.The Indian journal of medical research · 2015Article
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- Genomes of Two Clinical Isolates of Mycobacterium tuberculosis from Odisha, India.Genome announcements · 2014Article
- Whole-Genome Sequencing and Annotation of a Clinical Isolate of Mycobacterium tuberculosis from Mumbai, India.Genome announcements · 2014Article
- Whole-Genome Sequences of Four Clinical Isolates of Mycobacterium tuberculosis from Tamil Nadu, South India.Genome announcements · 2013Article
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- Whole-genome sequences of two clinical isolates of Mycobacterium tuberculosis from Kerala, South India.Journal of bacteriology · 2012Article
- First insights into the phylogenetic diversity of Mycobacterium tuberculosis in Nepal.PloS one · 2012Article
- SNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexes.PloS one · 2011Article
- Changes in Mycobacterium tuberculosis genotype families over 20 years in a population-based study in Northern Malawi.PloS one · 2010Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Mycobacterium tuberculosis is a very important global pathogen. One quarter of the world's TB cases occur in India. The tuberculosis strains isolated from south Indian patients exhibit certain phenotypic characteristics like low virulence in guinea-pigs, resistance to isoniazid, thiophene-2-carboxylic acid hydrazide (TCH) and para-amino salicylic acid (PAS), and enhanced susceptibility to H2O2. Besides this, a large percentage of the isolates harbor only a single copy of IS 6110 which makes these strains distinct. Hence, we have studied the genotypic characteristics of these strains by using advanced techniques like Deletion Micro array, deletion PCR, allelic discrimination RT-PCR using several lineage specific markers and KatG G1388T (non-synonymous) polymorphism along with spoligotyping. The analysis of 1215 tuberculosis patient isolates from south India revealed that 85.2% belonged to the ancestral lineage of M. tuberculosis. Comparative whole-genome hybridization identified six new genomic regions within this lineage that were variably deleted.
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