ArticleGene expression patterns : GEP2008
The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues.
Article in Gene expression patterns : GEP, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Pooled it
- Lysine Methylation-Dependent Proteolysis by the Malignant Brain Tumor (MBT) Domain Proteins.International journal of molecular sciences · 2024Review
- The regulatory roles of small nucleolar RNAs within their host locus.RNA biology · 2024Review
- Pinpointing miRNA and genes enrichment over trait-relevant tissue network in Genome-Wide Association Studies.BMC medical genomics · 2020Article
- Article
- Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas.Nature communications · 2020Article
- Roles and regulation of histone methylation in animal development.Nature reviews. Molecular cell biology · 2019Review
- Aberrant imprinting in mouse trophoblast stem cells established from somatic cell nuclear transfer-derived embryos.Epigenetics · 2018Article
- Imprinted MicroRNA Gene Clusters in the Evolution, Development, and Functions of Mammalian Placenta.Frontiers in genetics · 2018Review
- Article
- SFMBT2 (Scm-like with four mbt domains 2) negatively regulates cell migration and invasion in prostate cancer cells.Oncotarget · 2016Article
- Differential miRNA expression in inherently high- and low-active inbred mice.Physiological reports · 2015Article
- What does genetics tell us about imprinting and the placenta connection?Cellular and molecular life sciences : CMLS · 2015Review
- Chromatin regulation: how complex does it get?Epigenetics · 2014Review
- Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Review
- The imprinted polycomb group gene Sfmbt2 is required for trophoblast maintenance and placenta development.Development (Cambridge, England) · 2013Article
- Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice.Disease models & mechanisms · 2013Article
- Imprinted silencing is extended over broad chromosomal domains in mouse extra-embryonic lineages.Current opinion in cell biology · 2013Review
- SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors.Genes & development · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Genomic imprinting has dramatic effects on placental development, as has been clearly observed in interspecific hybrid, somatic cell nuclear transfer, and uniparental embryos. In fact, the earliest defects in uniparental embryos are evident first in the extraembryonic trophoblast. We performed a microarray comparison of gynogenetic and androgenetic mouse blastocysts, which are predisposed to placental pathologies, to identify imprinted genes. In addition to identifying a large number of known imprinted genes, we discovered that the Polycomb group (PcG) gene Sfmbt2 is imprinted. Sfmbt2 is expressed preferentially from the paternal allele in early embryos, and in later stage extraembryonic tissues. A CpG island spanning the transcriptional start site is differentially methylated on the maternal allele in e14.5 placenta. Sfmbt2 is located on proximal chromosome 2, in a region known to be imprinted, but for which no genes had been identified until now. This possibly identifies a new imprinted domain within the murine genome. We further demonstrate that murine SFMBT2 protein interacts with the transcription factor YY1, similar to the Drosophila PHO-RC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.