ReviewNeuroscience and biobehavioral reviews2008
A final common pathway for depression? Progress toward a general conceptual framework.
Review in Neuroscience and biobehavioral reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 84 citations in OpenAlex.
- Evaluation of salivary stress markers and inflammatory cytokine levels in peri-implantitis patients.Clinical oral investigations · 2024Article
- Downregulated NPAS4 in multiple brain regions is associated with major depressive disorder.Scientific reports · 2023Article
- PACAP Controls Endocrine and Behavioral Stress Responses via Separate Brain Circuits.Biological psychiatry global open science · 2023Article
- Time to re-engage psychiatric drug discovery by strengthening confidence in preclinical psychopharmacology.Psychopharmacology · 2021Review
- Computational Analysis of Therapeutic Neuroadaptation to Chronic Antidepressant in a Model of the Monoaminergic Neurotransmitter and Stress Hormone Systems.Frontiers in pharmacology · 2019Article
- Repeated social defeat-induced neuroinflammation, anxiety-like behavior and resistance to fear extinction were attenuated by the cannabinoid receptor agonist WIN55,212-2.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Distributional patterns of item responses and total scores on the PHQ-9 in the general population: data from the National Health and Nutrition Examination Survey.BMC psychiatry · 2018Article
- Exponential distribution of total depressive symptom scores in relation to exponential latent trait and item threshold distributions: a simulation study.BMC research notes · 2017Article
- Computational Model of Antidepressant Response Heterogeneity as Multi-pathway Neuroadaptation.Frontiers in pharmacology · 2017Article
- Realist theory construction for a mixed method multilevel study of neighbourhood context and postnatal depression.SpringerPlus · 2016Article
- Being alone and expectations lost: a critical realist study of maternal depression in South Western Sydney.SpringerPlus · 2015Article
- Explaining ecological clusters of maternal depression in South Western Sydney.BMC pregnancy and childbirth · 2014Article
- PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress.Psychoneuroendocrinology · 2013Article
- The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice.The international journal of neuropsychopharmacology · 2013Article
- Six months of dance intervention enhances postural, sensorimotor, and cognitive performance in elderly without affecting cardio-respiratory functions.Frontiers in aging neuroscience · 2013 · on this mapArticle
- Anxiety- rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety- and comorbid depression-like behavior.Translational psychiatry · 2012Article
- Inflammation in neurological and psychiatric diseases.Inflammopharmacology · 2012Review
- Role of vascular endothelial growth factor in adult hippocampal neurogenesis: implications for the pathophysiology and treatment of depression.Behavioural brain research · 2012Review
- Convergent mechanisms in etiologically-diverse dystonias.Expert opinion on therapeutic targets · 2011Review
- The autism diagnosis in translation: shared affect in children and mouse models of ASD.Autism research : official journal of the International Society for Autism Research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Functional neuroimaging studies of depressed patients have converged with functional brain mapping studies of depressed animals in showing that depression is accompanied by a hypoactivity of brain regions involved in positively motivated behavior together with a hyperactivity in regions involved in stress responses. Both sets of changes are reversed by diverse antidepressant treatments. It has been proposed that this neural pattern underlies the symptoms common to most forms of the depression, which are the loss of positively motivated behavior and increased stress. The paper discusses how this framework can organize diverse findings ranging from effects of monoamine neurotransmitters, cytokines, corticosteroids and neurotrophins on depression. The hypothesis leads to new insights concerning the relationship between the prolonged inactivity of the positive motivational network during a depressive episode and the loss of neurotrophic support, the potential antidepressant action of corticosteroid treatment, and to the key question of whether antidepressants act by inhibiting the activity of the stress network or by enhancing the activity of the positive motivational system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.