ReviewCurrent topics in developmental biology2008
Coordinated action of N-CAM, N-cadherin, EphA4, and ephrinB2 translates genetic prepatterns into structure during somitogenesis in chick.
Review in Current topics in developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Sequential changes in cellular properties accompanying amniote somite formation.Journal of anatomy · 2023Article
- A mechanical model of early somite segmentation.iScience · 2021Article
- A multiscale model via single-cell transcriptomics reveals robust patterning mechanisms during early mammalian embryo development.PLoS computational biology · 2021Article
- Continuous Dynamic Modeling of Regulated Cell Adhesion: Sorting, Intercalation, and Involution.Biophysical journal · 2019Article
- Development of the axial skeleton and intervertebral disc.Current topics in developmental biology · 2019Review
- Location, Location, Location: Signals in Muscle Specification.Journal of developmental biology · 2018Review
- Mechanics of tissue compaction.Seminars in cell & developmental biology · 2015Review
- Signaling mechanisms controlling cranial placode neurogenesis and delamination.Developmental biology · 2014Review
- Ephrin-Eph signaling in embryonic tissue separation.Cell adhesion & migration · 2014Review
- A computational model predicting disruption of blood vessel development.PLoS computational biology · 2013Article
- Cell-based multi-parametric model of cleft progression during submandibular salivary gland branching morphogenesis.PLoS computational biology · 2013Article
- Adhesion failures determine the pattern of choroidal neovascularization in the eye: a computer simulation study.PLoS computational biology · 2012Article
- Multi-scale modeling of tissues using CompuCell3D.Methods in cell biology · 2012Article
- Eph/ephrin interactions modulate muscle satellite cell motility and patterning.Development (Cambridge, England) · 2011Article
- A multi-cell, multi-scale model of vertebrate segmentation and somite formation.PLoS computational biology · 2011Review
- Article
- Computer simulation of cellular patterning within the Drosophila pupal eye.PLoS computational biology · 2010Article
- 3D multi-cell simulation of tumor growth and angiogenesis.PloS one · 2009Article
- Eph/ephrin signaling in epithelial development and homeostasis.The international journal of biochemistry & cell biology · 2009Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
During gastrulation in vertebrates, mesenchymal cells at the anterior end of the presomitic mesoderm (PSM) periodically compact, transiently epithelialize and detach from the posterior PSM to form somites. In the prevailing clock-and-wavefront model of somitogenesis, periodic gene expression, particularly of Notch and Wnt, interacts with an FGF8-based thresholding mechanism to determine cell fates. However, this model does not explain how cell determination and subsequent differentiation translates into somite morphology. In this paper, we use computer simulations of chick somitogenesis to show that experimentally-observed temporal and spatial patterns of adhesive N-CAM and N-cadherin and repulsive EphA4-ephrinB2 pairs suffice to reproduce the complex dynamic morphological changes of somitogenesis in wild-type and N-cadherin (-/-) chick, including intersomitic separation, boundary-shape evolution and sorting of misdifferentiated cells across compartment boundaries. Since different models of determination yield the same, experimentally-observed, distribution of adhesion and repulsion molecules, the patterning is independent of the details of this mechanism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.