ArticleMolecular immunology2008
AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.
Article in Molecular immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Diversification of immunoglobulin genes by gene conversion in the domestic chicken (Discovery immunology · 2023Article
- Separation of mutational and transcriptional enhancers in Ig genes.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Article
- Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.PLoS genetics · 2009Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Somatic hypermutation (SHM) and gene conversion (GCV) are closely related processes that increase the diversity the primary immunoglobulin repertoire. In both processes the activation-induced cytidine deaminase (AID) converts cytosine residues to uracils within the DNA of the immunoglobulin (Ig) genes in a transcription-dependent manner, and subsequent error-prone repair processes lead to changes in the antigen recognition site of the encoded receptors. This activity is specifically recruited to the Ig loci by unknown mechanisms. Our analyses of the chicken B-cell line DT40, and derivatives thereof, now revealed that even the closest neighbors of the Ig light chain (IgL) gene are protected from AID activity, albeit being transcribed and thus acting as potential targets of AID. Our findings are in support of a model in which cis-acting DNA boundary elements restrict AID activity to the IgL locus and guard the genome in the vicinity of the IgL gene from deleterious mutations.
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