ReviewThe international journal of biochemistry & cell biology2008
Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan.
Review in The international journal of biochemistry & cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 47 citations in OpenAlex.
- Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis inScience translational medicine · 2025Article
- Anti-inflammatory and Anti-proliferative Role of Essential Oil of Leaves ofAnti-cancer agents in medicinal chemistry · 2025Article
- SIRT7: the seventh key to unlocking the mystery of aging.Physiological reviews · 2024Review
- Unraveling the mechanisms of intervertebral disc degeneration: an exploration of the p38 MAPK signaling pathway.Frontiers in cell and developmental biology · 2023Review
- Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms.Frontiers in aging · 2022Review
- NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing.Frontiers in cell and developmental biology · 2022Review
- Metformin reverses the effects of high glucose on human dermal fibroblasts of aged skin via downregulating RELA/p65 expression.Journal of physiology and biochemistry · 2021Article
- Effects of Amyloid Precursor Protein Overexpression on NF-κB, Rho-GTPase and Pro-Apoptosis Bcl-2 Pathways in Neuronal Cells.Reports of biochemistry & molecular biology · 2021Article
- Cross-Species and Human Inter-Tissue Network Analysis of Genes Implicated in Longevity and Aging Reveal Strong Support for Nutrient Sensing.Frontiers in genetics · 2021Article
- Pathomechanism of intervertebral disc degeneration.JOR spine · 2020Review
- Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice.Molecular therapy. Methods & clinical development · 2019Article
- Molecular Mechanisms of Intervertebral Disc Degeneration.Spine surgery and related research · 2019Review
- Cellular senescence in intervertebral disc aging and degeneration.Current molecular biology reports · 2018Article
- Oxidative Stress in Stem Cell Aging.Cell transplantation · 2017Article
- mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Comparative analysis of signaling pathways in peripheral blood from patients with Kashin-Beck disease and osteoarthritis.Experimental and therapeutic medicine · 2016Article
- Non-canonical roles for caveolin in regulation of membrane repair and mitochondria: implications for stress adaptation with age.The Journal of physiology · 2016Review
- Molecular mechanisms of biological aging in intervertebral discs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Review
- The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes.Frontiers in molecular neuroscience · 2015Review
- Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ageing is defined by the loss of functional reserve over time, leading to a decreased capacity to maintain homeostasis under stress and increased risk of morbidity and mortality. Ageing is extremely heterogeneous between individuals and even between tissues within an organism, making it challenging to identify the molecular basis of ageing. Much of our current understanding of ageing comes from genetic studies in model organisms seeking genes that either accelerate or decelerate the ageing process. These studies revealed not only causes of ageing, but also signaling mechanisms that both promote and protect against ageing. In all cases, the signaling pathways that influence lifespan are familiar mechanisms that regulate cellular metabolism, growth, proliferation, differentiation and survival. This review highlights the significant overlap in signaling mechanisms implicated in both the cellular response to genotoxic stress and regulation of organism lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.