SynthesisSchizophrenia research2008
Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis.
Synthesis in Schizophrenia research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.Journal of molecular neuroscience : MN · 2012Pooled it
- Further evidence for an association of G72/G30 with schizophrenia in Chinese.Schizophrenia research · 2009Pooled it
- Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.Schizophrenia research · 2008Pooled it
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Locus-Specific Genetic Associations at theAdvanced genetics (Hoboken, N.J.) · 2026Article
- Gene Polymorphisms and Expression ofNeuropsychiatric disease and treatment · 2023Article
- d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia.International journal of molecular sciences · 2021Review
- Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia.Brain imaging and behavior · 2021Article
- Increased excitation-inhibition balance and loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction.Journal of neurophysiology · 2021Article
- Supplementation with D-serine prevents the onset of cognitive deficits in adult offspring after maternal immune activation.Scientific reports · 2016Article
- Genetic variation in the G72 gene is associated with increased frontotemporal fiber tract integrity.European archives of psychiatry and clinical neuroscience · 2015Article
- Epistatic Interactions between CREB and CREM Variants in Affective Disorder.Psychiatry investigation · 2014Article
- Pre-clinical models of neurodevelopmental disorders: focus on the cerebellum.Reviews in the neurosciences · 2014Review
- Clinical and molecular genetics of psychotic depression.Schizophrenia bulletin · 2013Review
- Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis.Translational psychiatry · 2013Article
- Schizophrenia susceptibility and NMDA-receptor mediated signalling: an association study involving 32 tagSNPs of DAO, DAOA, PPP3CC, and DTNBP1 genes.BMC medical genetics · 2013Article
- Evidence for single nucleotide polymorphisms and their association with bipolar disorder.Neuropsychiatric disease and treatment · 2013Review
- The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex.Neurobiology of disease · 2012Article
- Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.Handbook of experimental pharmacology · 2012Review
- D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The G72/G30 gene complex (G72 also known as D-amino acid oxidase activator, DAOA) and its chromosomal region 13q32-34 have been linked and associated with both schizophrenia (SCZ) and bipolar disorder (BP) in multiple studies, including our initial association report on BP. However, the inconsistency of associated variants across studies is obvious. Previous meta-analyses had small data sets. The present meta-analysis combined 18 association articles published before April of 2007. There were 19 independent studies of SCZ, with 4304 cases, 5423 controls, and 1384 families, and four independent studies of BP with 1145 cases, 1829 controls, and 174 families. Of 15 single nucleotide polymorphisms (SNPs) analyzed in the 95-kb G72/G30 gene region, M18/rs947267 and M22/rs778293 showed association with SCZ in Asians, and M24/rs1421292 with SCZ in Europeans. The associations of C allele at M18 and A allele at M22 with SCZ in Asians survived conservative Bonferroni correction for multiple testing for 15 markers and subgroup analysis (adjusted P=0.0000253 for M18; adjusted P=0.009 for M22). No single maker showed evidence of overall association with BP. These results suggest that G72/G30 may influence susceptibility to schizophrenia with weak effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.