Evidence map›Paper›PMID 18022379›Full record

ArticleAnalytical biochemistry2008

Do zwitterions contribute to the ionic strength of a solution?

Earle Stellwagen, Jason D Prantner, Nancy C Stellwagen

Abstract read
In one paragraph

Article in Analytical biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Zwitterions Layer at but Do Not Screen Electrified Interfaces.The journal of physical chemistry. B · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  17. Buffers Strongly Modulate Fibrin Self-Assembly into Fibrous Networks.Langmuir : the ACS journal of surfaces and colloids · 2017
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Earle StellwagenDepartment of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.
Jason D Prantner
Nancy C Stellwagen

Funding

FREE SOLUTION MOBILITY AS A PROBE OF DNA ELECTROSTATICSR01GM061009 · NIGMS · UNIVERSITY OF IOWA · PI STELLWAGEN, NANCY C · 2001 to 2004
$958k
NIGMS NIH HHS GM61009NIGMS NIH HHS R01 GM061009
6 · The paper itself

Abstract

Capillary electrophoresis has been used to determine whether zwitterions contribute to the ionic strength of a solution, by measuring the mobility of a double-stranded DNA oligomer in cacodylate-buffered solutions containing various concentrations of the ionic salt tetraethylammonium chloride (TEA(+)Cl(-)) or the zwitterion tricine(+/-). The mobility of the DNA decreased as the square root of ionic strength, as expected from the Debye-Hückel-Onsager theory of electrophoresis, when TEA(+)Cl(-) was added to the buffer. However, the mobility was independent of the concentration of added tricine(+/-). Hence, zwitterions do not contribute to the ionic strength of a solution.

Indexed as

Osmolar ConcentrationDNAElectrophoresis, CapillaryGlycineIonsSolutionsTetraethylammoniumDNAGlycineIonsSolutionsTetraethylammoniumtricine

Identifiers

PMID18022379
PMCPMC2248451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.