Evidence map›Paper›PMID 18022111›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Correction of iodine-123-labeled meta-iodobenzylguanidine uptake with multi-window methods for standardization of the heart-to-mediastinum ratio.

Kenichi Nakajima, Kosuke Matsubara, Takehiro Ishikawa, Nobutoku Motomura, Ryo Maeda, Nasima Akhter, Koichi Okuda, Junichi Taki, Seigo Kinuya

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. An improved method for estimating the heart-to-mediastinum ratio from cardiac sympathetic nerve imaging with low-energy high-resolution collimators.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014
    Trial
  3. Article
  4. Machine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  5. Article
  6. Article
  7. The utility of heart-to-mediastinum ratio using a planar image created from IQ-SPECT with Iodine-123 meta-iodobenzylguanidine.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  8. Article
  9. Article
  10. A European myocardialJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  11. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  12. Correction of collimator-dependent differences in the heart-to-mediastinum ratio inJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
  13. Cross calibration ofAnnals of nuclear medicine · 2017
    Article
  14. Standardization ofClinical and translational imaging · 2017
    Review
  15. Review
  16. Review
  17. Review
  18. Quantification of I-123-meta-iodobenzylguanidine heart-to-mediastinum ratios: not so simple after all.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014
    Article
  19. Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kenichi NakajimaDepartment of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. nakajima@med.kanazawa-u.ac.jp
Kosuke Matsubara
Takehiro Ishikawa
Nobutoku Motomura
Ryo Maeda
Nasima Akhter
Koichi Okuda
Junichi Taki
Seigo Kinuya

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo overcome differences in the choice of collimator for an iodine-123 ((123)I)-labeled meta-iodobenzylguanidine (MIBG) heart-to-mediastinum (H/M) ratio, we examined multi-window correction methods with (123)I dual-window (IDW) and triple-energy window (TEW) acquisition. METHODS AND

resultsStandard phantoms, which consisted of the heart, mediastinum, lung, and liver, were generated. Three correction methods were compared: TEW and two IDW methods (IDW(0) and IDW(1)). Low-energy high-resolution (LEHR), medium-energy (ME), and (123)I-specific low-medium-energy high-resolution (LMEHR) collimators were used. Clinical studies were performed in 10 patients. In the phantom study, the H/M ratio was significantly underestimated without correction, with both the LEHR and ME collimators (70% and 88% of the true value). When H/M with the LEHR collimator was divided by uncorrected H/M with the ME collimator, the ratio (mean +/- SD) was 80% +/- 5%, 98% +/- 5%, 104% +/- 7%, and 98% +/- 5% for the no-correction, TEW, IDW(0), and IDW(1) methods, respectively. Clinical studies with the LEHR collimator after TEW and IDW correction (uncorrected average H/M ratio, 1.86 +/- 0.23; TEW, 2.47 +/- 0.46, P = .0015; IDW, 2.46 +/- 0.46, P = .0017) provided comparable values to the uncorrected ME collimator (2.56 +/- 0.46, P = NS vs TEW and IDW).

conclusionsThe H/M ratio with the ME collimator, after application of the TEW or IDW methods, was close to the theoretical value in the phantom study. However, the corrected H/M ratios with the LEHR collimator provided comparable H/M ratios to the uncorrected ME data in phantom and clinical studies.

Indexed as

Phantoms, Imaging3-IodobenzylguanidineArtifactsCalibrationHeartHumansImage EnhancementImage Interpretation, Computer-AssistedMediastinumMyocardiumPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsSensitivity and Specificity3-IodobenzylguanidineRadiopharmaceuticals

Identifiers

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.